Rabbit DYRK3 Polyclonal Antibody | anti-DYRK3 antibody

DYRK3 Polyclonal Antibody

Cat. Num. AAA268295

• Gene Names: DYRK3; RED; REDK; DYRK5; hYAK3-2
• Reactivity: Human; Mouse; Rat
• Applications: ELISA, Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: DYRK3, Antibody; DYRK3 Polyclonal Antibody; Dual specificity tyrosine-phosphorylation-regulated kinase 3; EC 2.7.12.1; Regulatory erythroid kinase; REDK; DYRK3; anti-DYRK3 antibody

• Host: Rabbit
• Reactivity: Human; Mouse; Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: DYRK3 Polyclonal Antibody detects endogenous levels of protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)

• Applicable Applications for anti-DYRK3 antibody: ELISA, WB (Western Blot)
• Immunogen: Synthesized peptide derived from human protein at AA range: 1-80.
• Subcellular Location: Nucleus . Cytoplasm . Nucleus speckle . Cytoplasmic granule . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with membraneless organelles in the cytoplasm and nucleus (PubMed: 29973724). Shuttles between cytoplasm and stress granules (PubMed: 20167603). Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed :20167603). At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed: 20167603).
• Expression: Isoform 1: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 1: Predominant form in fetal liver and bone marrow (PubMed:10779429). Isoform 1: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). Isoform 2: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 2: Predominant form in testis. Isoform 2: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429).
• Preparation and Storage: -15°C to -25°C/1 year(Do not lower than -25°C)

WB (Western Blot)

(Western Blot analysis of DYRK3 in HTERT-HME1 cells lysates using DYRK3 antibody.)

Related Product Information for anti-DYRK3 antibody

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008], Function:catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor: Magnesium., function: Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.,induction:By erythropoietin.,PTM:Autophosphorylated on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in testis where isoform 2 is the predominant form and in hematopoietic tissue such as fetal liver, and bone marrow where isoform 1 predominates. Both isoforms are present at low levels in heart, pancreas, lymph node, and thymus.,

NCBI and Uniprot Product Information

• NCBI GI #: 51702242
• NCBI GeneID: 8444
• NCBI Accession #: NP_001004023.1
• NCBI GenBank Nucleotide #: NM_001004023.1
• UniProt Accession #: O43781; Q7Z752; Q9HBY6; Q9HBY7; D3DT79
• Molecular Weight: 64kD
• NCBI Official Full Name: dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b
• NCBI Official Synonym Full Names: dual specificity tyrosine phosphorylation regulated kinase 3
• NCBI Official Symbol: DYRK3
• NCBI Official Synonym Symbols: RED; REDK; DYRK5; hYAK3-2
• NCBI Protein Information: dual specificity tyrosine-phosphorylation-regulated kinase 3
• UniProt Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 3
• UniProt Gene Name: DYRK3
• UniProt Synonym Gene Names: REDK