Rabbit EPAC2 Polyclonal Antibody | anti-RAPGEF4 antibody

EPAC2 Antibody

Cat. Num. AAA39719

• Gene Names: RAPGEF4; 2; EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: EPAC2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: EPAC2, Antibody; EPAC2 Antibody; EPAC2; 2; EPAC; CGEF2; EPAC 2; Nbla00496; CAMP-GEFII; Rap guanine nucleotide exchange factor 4; Exchange factor directly activated by cAMP 2; Rap guanine nucleotide exchange factor (GEF) 4; anti-RAPGEF4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of EPAC2 are known to exist; this antibody will detect only the larger isoform. EPAC2 antibody is predicted to not cross-react with EPAC2
• Purity/Purification: EPAC2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1011

• Applicable Applications for anti-RAPGEF4 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: EPAC2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human EPAC2.
• Buffer: EPAC2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: EPAC2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of EPAC2 in mouse liver tissue with EPAC2 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of EPAC3 in mouse liver tissue with EPAC3 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of EPAC2 in rat liver tissue lysate with EPAC2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-RAPGEF4 antibody

EPAC2 Antibody: EPAC2, also known as Rap guanine nuclear exchange factor 4 and cAMPGEF-II, is belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins with guanine nucleotide exchange factor. Like the related protein EPAC1, EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, and inflammation. Recent evidence suggests that EPAC2 induces synapse remodeling and depression, with mutations in its gene being found in patients with autism.

NCBI and Uniprot Product Information

• NCBI GI #: 155030204
• NCBI GeneID: 11069
• NCBI Accession #: NP_008954
• NCBI GenBank Nucleotide #: NM_007023.3
• UniProt Accession #: Q8WZA2; O95636; Q8IXK6; Q8TAA4; B2R7R3; B7Z283; B7Z3T6; B7Z912
• Molecular Weight: 96,269 Da
• NCBI Official Full Name: rap guanine nucleotide exchange factor 4 isoform a
• NCBI Official Synonym Full Names: Rap guanine nucleotide exchange factor (GEF) 4
• NCBI Official Symbol: RAPGEF4
• NCBI Official Synonym Symbols: 2; EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
• NCBI Protein Information: rap guanine nucleotide exchange factor 4; putative protein product of Nbla00496; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; RAP guanine-nucleotide-exchange factor (GEF) 4; cAMP-regulated guanine nucleotide exchange factor II
• UniProt Protein Name: Rap guanine nucleotide exchange factor 4
• UniProt Gene Name: RAPGEF4
• UniProt Synonym Gene Names: CGEF2; EPAC2; EPAC 2; cAMP-GEFII
• UniProt Entry Name: RPGF4_HUMAN