Rabbit anti-Mouse, Rat ERK 1/2 Polyclonal Antibody | anti-ERK1 antibody

ERK 1/2 Polyclonal Antibody

Cat. Num. AAA174067

• Gene Names: Mapk3; p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Antigen Affinity Purification
• Synonyms: ERK 1/2, Antibody; ERK 1/2 Polyclonal Antibody; MAPK3; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p; anti-ERK1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
• Concentration: 0.25 mg/mL (varies by lot)
• Sequence Length: 406

• Applicable Applications for anti-ERK1 antibody: WB (Western Blot)
• Immunogen: Recombinant Rat Mitogen-activated protein kinase 3 protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

WB (Western Blot)

(Western Blot analysis of NIH/3T3 cells using Mapk3 Polyclonal Antibody at dilution of 1:500)

WB (Western Blot)

(Western Blot analysis of Rat brain using Mapk3 Polyclonal Antibody at dilution of 1:500)

Related Product Information for anti-ERK1 antibody

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described;This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Product Categories/Family for anti-ERK1 antibody

Cnacer; Signal Transduction; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 8393331
• NCBI GeneID: 50689
• NCBI Accession #: NP_059043.1
• NCBI GenBank Nucleotide #: NM_017347.2
• UniProt Accession #: P21708; Q4PIY8; Q62686; Q9JJ13
• Molecular Weight: Calculated: 43,46 kDa; Observed: 43; 46 kDa
• NCBI Official Full Name: mitogen-activated protein kinase 3
• NCBI Official Synonym Full Names: mitogen activated protein kinase 3
• NCBI Official Symbol: Mapk3
• NCBI Official Synonym Symbols: p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk
• NCBI Protein Information: mitogen-activated protein kinase 3
• UniProt Protein Name: Mitogen-activated protein kinase 3
• UniProt Gene Name: Mapk3
• UniProt Synonym Gene Names: Erk1; Prkm3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK