IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ERN2 Polyclonal Antibody at dilution 1:40)
Rabbit anti-Human ERN2 Polyclonal Antibody | anti-ERN2 antibody
ERN2 Polyclonal Antibody
Gene Names
ERN2; IRE1b; IRE1-BETA
Reactivity
Human
Applications
Immunohistochemistry
Purity
Affinity purification
Synonyms
ERN2, Antibody; ERN2 Polyclonal Antibody; IRE1b; IRE1-BETA; anti-ERN2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purification
Form/Format
Phosphate buffered solution, pH 7.4, containing 0.05% stabilzer and 50% glycerol
Sequence Length
926
Applicable Applications for anti-ERN2 antibody
IHC (Immunohistochemistry)
Immunogen
Synthetic peptide of human ERN2
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ERN2 Polyclonal Antibody at dilution 1:40)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ERN2 Polyclonal Antibody at dilution 1:40)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ERN2 Polyclonal Antibody at dilution 1:40)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ERN2 Polyclonal Antibody at dilution 1:40)
Related Product Information for anti-ERN2 antibody
The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1alpha and IRE1beta are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
Product Categories/Family for anti-ERN2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
ERN2 protein
NCBI Official Synonym Full Names
endoplasmic reticulum to nucleus signaling 2
NCBI Official Symbol
ERN2
NCBI Official Synonym Symbols
IRE1b; IRE1-BETA
NCBI Protein Information
serine/threonine-protein kinase/endoribonuclease IRE2; ER to nucleus signalling 2; ERN2; IRE1 beta; IRE1, S. cerevisiae, homolog of; endoplasmic reticulum to nucleus signalling 2; endoplasmic reticulum-to-nucleus signaling 2; hIRE2p; inositol-requiring 1 beta; inositol-requiring protein 2
UniProt Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Gene Name
ERN2
UniProt Synonym Gene Names
hIRE2p; IRE1b
UniProt Entry Name
ERN2_HUMAN
Similar Products
Product Notes
The ERN2 ern2 (Catalog #AAA168046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERN2 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERN2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the ERN2 ern2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.