Rabbit anti-Human EXOSC5 Polyclonal Antibody | anti-EXOSC5 antibody

EXOSC5 Antibody

Cat. Num. AAA229589

• Gene Names: EXOSC5; p12B; RRP46; RRP41B; Rrp46p; hRrp46p
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: >95%, Protein G purified
• Synonyms: EXOSC5, Antibody; EXOSC5 Antibody; Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B); EXOSC5; CML28 RRP46; anti-EXOSC5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 235

• Applicable Applications for anti-EXOSC5 antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen: Recombinant Human Exosome complex component RRP46 protein (1-235AA)
• Immunogen Species: Homo sapiens (Human)
• Research Area: Epigenetics and Nuclear Signaling
• Target: Names EXOSC5
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-131154
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded human breast cancer tissue using AAA229589 at dilution 1:100)

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded human testis tissue using AAA229589 at dilution 1:100)

WB (Western Blot)

(Western blotAll lanes: EXOSC5 antibody at 5ug/mlLane 1:K562 whole cell lysateLane 2:293T whole cell lysateLane 3:Hela whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 25kDaObserved band size: 25kDa)

Related Product Information for anti-EXOSC5 antibody

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

NCBI and Uniprot Product Information

• NCBI GI #: 47174864
• NCBI GeneID: 56915
• NCBI Accession #: NP_064543.3
• NCBI GenBank Nucleotide #: NM_020158.3
• UniProt Accession #: Q9NQT4; Q32Q81; Q8NG16; Q96I89
• NCBI Official Full Name: exosome complex component RRP46
• NCBI Official Synonym Full Names: exosome component 5
• NCBI Official Symbol: EXOSC5
• NCBI Official Synonym Symbols: p12B; RRP46; RRP41B; Rrp46p; hRrp46p
• NCBI Protein Information: exosome complex component RRP46
• UniProt Protein Name: Exosome complex component RRP46
• UniProt Gene Name: EXOSC5
• UniProt Synonym Gene Names: CML28; RRP46
• UniProt Entry Name: EXOS5_HUMAN