Rabbit FAF1 Polyclonal Antibody | anti-FAF1 antibody

FAF1 Antibody

Cat. Num. AAA40057

• Gene Names: FAF1; hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: FAF1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: FAF1, Antibody; FAF1 Antibody; FAF1; hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A; FAS-associated factor 1; UBX domain-containing protein 12; Fas (TNFRSF6) associated factor 1; anti-FAF1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: FAF1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 650

• Applicable Applications for anti-FAF1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: FAF1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FAF1.
• Buffer: FAF1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: FAF1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of FAF1 in rat spleen tissue with FAF1 antibody at 2 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of FAF1 in rat spleen tissue with FAF1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of FAF1 in THP-1 cell lysate with FAF1 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-FAF1 antibody

FAF1 Antibody: Fas-associated protein 1 (FAF1) was initially identified as a Fas-binding pro-apoptotic protein that is component of the death-inducing signaling complex in Fas-mediated apoptosis. FAF1 can also induce apoptosis in the absence of extrinsic death signals when overexpressed although it does not contain typical death motifs such as the death domain, death effector domain, and caspase recruitment domain. Overexpression of FAF1 also decreases the basal level of NF-κB activity in transfected 293 cells, inhibits NF-κB activity induced by TNF-α, IL-1β and lipopolysaccharide, and prevents NF-κB translocation to the nucleus, suggesting that another role of FAF1 is to negatively regulate the activity of NF-κB. FAF1 can also interact with the inflammatory signaling PYRIN-containing Apaf-1-like proteins (PYPAFs, also called NALPs) such as PYPAF1, PYPAF2 (NALP2), and PYPAF7, suggesting FAF1 may also be involved in the inflammation pathway. Multiple differentially spliced isoforms of FAF1 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 5901948
• NCBI GeneID: 11124
• NCBI Accession #: NP_008982
• NCBI GenBank Nucleotide #: NM_007051.2
• UniProt Accession #: Q9UNN5; Q549F0; Q9UF34; Q9UNT3; Q9Y2Z3
• Molecular Weight: 56,934 Da
• NCBI Official Full Name: FAS-associated factor 1
• NCBI Official Synonym Full Names: Fas (TNFRSF6) associated factor 1
• NCBI Official Symbol: FAF1
• NCBI Official Synonym Symbols: hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A
• NCBI Protein Information: FAS-associated factor 1; UBX domain protein 3A; TNFRSF6-associated factor 1; UBX domain-containing protein 12; UBX domain-containing protein 3A
• UniProt Protein Name: FAS-associated factor 1
• UniProt Gene Name: FAF1
• UniProt Synonym Gene Names: UBXD12; UBXN3A; hFAF1
• UniProt Entry Name: FAF1_HUMAN