Rabbit anti-Human FBXL2 Polyclonal Antibody | anti-FBXL2 antibody
FBXL2 Antibody, HRP conjugated
Gene Names
FBXL2; FBL2; FBL3
Reactivity
Human
Applications
ELISA
Purity
>95%, Protein G purified
Synonyms
FBXL2, Antibody; FBXL2 Antibody, HRP conjugated; F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3); FBXL2; FBL2 FBL3; anti-FBXL2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Sequence Length
355
Applicable Applications for anti-FBXL2 antibody
ELISA
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
HRP
Species
Homo sapiens (Human)
Research Area
Epigenetics and Nuclear Signaling
Target Names
FBXL2
Immunogen
Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54358 / sc-54359 / sc-54360 / sc-54361
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Related Product Information for anti-FBXL2 antibody
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
F-box/LRR-repeat protein 2 isoform 2
NCBI Official Synonym Full Names
F-box and leucine-rich repeat protein 2
NCBI Official Symbol
FBXL2
NCBI Official Synonym Symbols
FBL2; FBL3
NCBI Protein Information
F-box/LRR-repeat protein 2
UniProt Protein Name
F-box/LRR-repeat protein 2
UniProt Gene Name
FBXL2
UniProt Entry Name
FBXL2_HUMAN
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Product Notes
The FBXL2 fbxl2 (Catalog #AAA118558) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FBXL2 Antibody, HRP conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FBXL2 can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the FBXL2 fbxl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBXL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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