ICC (Immunocytochemistry)
(Immunocytochemistry analysis of human small intestine tissue using AAA233395 at dilution of 1:100)
Rabbit anti-Human FBXW7 Polyclonal Antibody | anti-FBXW7 antibody
FBXW7 Antibody
Gene Names
FBXW7; AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10
Reactivity
Human
Applications
ELISA
Purity
>95%, Protein G purified
Synonyms
FBXW7, Antibody; FBXW7 Antibody; F-box/WD repeat-containing protein 7; Archipelago homolog; FBXW7; anti-FBXW7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Sequence Length
589
Applicable Applications for anti-FBXW7 antibody
ELISA
Immunogen
Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ICC (Immunocytochemistry)
(Immunocytochemistry analysis of human small intestine tissue using AAA233395 at dilution of 1:100)
ICC (Immunocytochemistry)
(Immunocytochemistry analysis of human small intestine tissue using AAA233395 at dilution of 1:100)
IHC (Immunohistochemistry)
(Immunohistochemistry analysis of human kidney tissue using AAA233395 at dilution of 1:100)
IHC (Immunohistochemistry)
(Immunohistochemistry analysis of human kidney tissue using AAA233395 at dilution of 1:100)
Related Product Information for anti-FBXW7 antibody
Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
66,120 Da
NCBI Official Full Name
F-box/WD repeat-containing protein 7 isoform 3
NCBI Official Synonym Full Names
F-box and WD repeat domain containing 7
NCBI Official Symbol
FBXW7
NCBI Official Synonym Symbols
AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10
NCBI Protein Information
F-box/WD repeat-containing protein 7
UniProt Protein Name
F-box/WD repeat-containing protein 7
UniProt Gene Name
FBXW7
UniProt Synonym Gene Names
hAgo
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Product Notes
The FBXW7 fbxw7 (Catalog #AAA233395) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FBXW7 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FBXW7 can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the FBXW7 fbxw7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBXW7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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