Fos B Polyclonal Antibody | anti-Fos B antibody

Anti-Fos B Antibody

Cat. Num. AAA46494

• Gene Names: FOSB; AP-1; G0S3; GOS3; GOSB
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunogen Affinity Purified
• Synonyms: Fos B, Antibody; Anti-Fos B Antibody; Protein fosB; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; fosB; FOSB_HUMAN; G0/G1 switch regulatory protein 3; G0S3; GOS 3; GOS B; GOS3; GOSB; MGC42291; Oncogene FOS B; Oncogene FOSB; Protein fos B; anti-Fos B antibody

• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 302

• Applicable Applications for anti-Fos B antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Fos B (264-291aa LPFQTSQDAPPNLTASLFTHSEVQVLGD), different from the related mouse sequence by two amino acids.
• Ig Type: Rabbit IgG
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

IHC (Immunohistochemistry)

(Anti- Fos B antibody, IHC(P)IHC(P): Human Pancreatic Cancer Tissue)

IHC (Immunohistochemisry)

(Anti- Fos B antibody, IHC(P)IHC(P): Rat Intestine Tissue)

IHC (Immunohiostchemistry)

(Anti- Fos B antibody, IHC(P)IHC(P): Mouse Intestine Tissue)

WB (Western Blot)

(Anti- Fos B antibody, Western blottingAll lanes: Anti Fos B at 0.5ug/ml)

Related Product Information for anti-Fos B antibody

Description: Rabbit IgG polyclonal antibody for Protein fosB(FOSB) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Background: FOSB, FBJ murine osteosarcoma viral oncogene homolog B, is a protein that, in humans, is encoded by the FOSB gene. FOSB is a member of Fos gene family which consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. The FOSB gene is mapped to 19q13.32. Delta FOSB is a truncated splice variant of FOSB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain, and is linked to changes in a number of other gene products such as CREB and sirtuins. Delta FosB also regulates the commitment of mesenchymal precursor cells to the adipocyte or osteoblast lineage.

References

1. Kelz, M. B., Chen, J., Carlezon, W. A., Jr., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., Tkatch, T., Baranauskas, G., Surmeier, D. J., Neve, R. L., Duman, R. S., Picciotto, M. R., Nestler, E. J.Expression of the transcription factor delta-FosB in the brain controls sensitivity to cocaine.Nature 401: 272-276, 1999. 2. Martin-Gallardo, A., McCombie, W. R., Gocayne, J. D., FitzGerald, M. G., Wallace, S., Lee, B. M. B., Lamerdin, J., Trapp, S., Kelley, J. M., Liu, L.-I., Dubnick, M., Johnston-Dow, L. A., Kerlavage, A. R., de Jong, P., Carrano, A., Fields, C., Venter, J. C.Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3.Nature Genet. 1: 34-39, 1992. 3. Nakabeppu, Y., Nathans, D.A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity.Cell 64: 751-759, 1991.

NCBI and Uniprot Product Information

• NCBI GI #: 166999783
• NCBI GeneID: 2354
• NCBI Accession #: NP_001107643.1
• NCBI GenBank Nucleotide #: NM_001114171.1
• UniProt Accession #: P53539; A8K9K5; A8VJE1; A8VJE6; A8VJF0; A8VJF3; A8VJF7; A8VJG1; A8VJG5; A8VJG9; E7EPR6; E9PHJ3
• Molecular Weight: 30,978 Da
• NCBI Official Full Name: protein fosB isoform 2
• NCBI Official Synonym Full Names: FosB proto-oncogene, AP-1 trancription factor subunit
• NCBI Official Symbol: FOSB
• NCBI Official Synonym Symbols: AP-1; G0S3; GOS3; GOSB
• NCBI Protein Information: protein fosB
• UniProt Protein Name: Protein fosB
• UniProt Gene Name: FOSB
• UniProt Synonym Gene Names: G0S3
• UniProt Entry Name: FOSB_HUMAN