Rabbit anti-Human GABRR2 Polyclonal Antibody | anti-GABRR2 antibody

GABRR2 Antibody (N-term)

Cat. Num. AAA290197

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Synonyms: GABRR2, Antibody; GABRR2 Antibody (N-term); Gamma-aminobutyric acid receptor subunit rho-2; GABA(A) receptor subunit rho-2; GABA(C) receptor; GABRR2; anti-GABRR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: This GABRR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human GABRR2.
• Purity/Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Length: 490

• Applicable Applications for anti-GABRR2 antibody: ELISA, WB (Western Blot)
• Immunogen Region: 37-65
• Function: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission. Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity).
• Cellular Location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P56476}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P56476}; Multi-pass membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(GABRR2 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GABRR2 antibody detected the GABRR2 protein (arrow).)

Related Product Information for anti-GABRR2 antibody

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex.

Product Categories/Family for anti-GABRR2 antibody

Neuroscience

References

Green, E.K., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (7), 1347-1349 (2010) :
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Xuei, X., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 418-427 (2010) :
Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :
Osolodkin, D.I., et al. J. Mol. Graph. Model. 27(7):813-821(2009)

NCBI and Uniprot Product Information

• NCBI GI #: 406035350
• NCBI GeneID: 2570
• NCBI Accession #: NP_002034.3
• NCBI GenBank Nucleotide #: NM_002043.3
• UniProt Accession #: P28476; Q9H153; A2BDE4
• Molecular Weight: 54151
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit rho-2
• NCBI Official Synonym Full Names: gamma-aminobutyric acid (GABA) A receptor, rho 2
• NCBI Official Symbol: GABRR2
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit rho-2
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit rho-2
• UniProt Gene Name: GABRR2
• UniProt Entry Name: GBRR2_HUMAN