Rabbit GAS6 Polyclonal Antibody | anti-GAS6 antibody

GAS6 Antibody

Cat. Num. AAA40827

• Gene Names: GAS6; AXSF; AXLLG
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column.
• Synonyms: GAS6, Antibody; GAS6 Antibody; Growth arrest-specific 6 protein, AXSF, AXLLG; anti-GAS6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform.
• Purity/Purification: Affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 678

• Applicable Applications for anti-GAS6 antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen: GAS6 antibody was raised against a 19 amino acid peptide from near the amino terminus of human GAS6.
• Buffer: Supplied in PBS containing 0.02% sodium azide.
• Positive Control 1: Mouse Heart Tissue Lysate
• Conjugate: Unconjugated
• Preparation and Storage: Store at 4 degree C for three months and -20 degree C, stable for up to one year.

IHC (Immunohiostchemistry)

(Immunohistochemistry of GAS6 in mouse heart tissue with GAS6 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of GAS6 in mouse heart tissue lysate with GAS6 antibody at 1 μg/ml.)

Related Product Information for anti-GAS6 antibody

The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla)-containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2). GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3). This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4). Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2).

Product Categories/Family for anti-GAS6 antibody

Apoptosis; Homeostasis

References

Schneider C, King RM, and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988; 54:787-93. Laurance S, Lemarie CA, and Blostein MD. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv. Nutr. 2012; 3:196-203. Stitt TN, Conn G, Gore M, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 1995; 80:661-70. van der Meer JH, van der Poll T, and van 't Veer C. TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis. Blood 2014; 123:2460-9.

NCBI and Uniprot Product Information

• NCBI GI #: 4557617
• NCBI GeneID: 2621
• NCBI Accession #: NP_000811
• NCBI GenBank Nucleotide #: NM_000820.3
• UniProt Accession #: Q14393; Q6IMN1; Q7Z7N3; B3KRQ7; B3KVL4; E9PBL7
• Molecular Weight: Predicted: 75 kDa; Observed: 75 kDa
• NCBI Official Full Name: growth arrest-specific protein 6
• NCBI Official Synonym Full Names: growth arrest specific 6
• NCBI Official Symbol: GAS6
• NCBI Official Synonym Symbols: AXSF; AXLLG
• NCBI Protein Information: growth arrest-specific protein 6
• UniProt Protein Name: Growth arrest-specific protein 6
• UniProt Gene Name: GAS6
• UniProt Synonym Gene Names: AXLLG; GAS-6
• UniProt Entry Name: GAS6_HUMAN