IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/15.)
Rabbit anti-Human GCH1 Polyclonal Antibody | anti-GCH1 antibody
GCH1 Antibody
Gene Names
GCH1; GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Antigen affinity purification.
Synonyms
GCH1, Antibody; GCH1 Antibody; GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1; anti-GCH1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total GCH1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
250
Applicable Applications for anti-GCH1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human GTP cyclohydrolase 1
Target Name
GCH1
Preparation and Storage
Store at -20 degree C
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/15.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/15.)
Application Data
(Gel: 12%SDS-PAGE Lysates (from left to right): Human fetal liver tissue and hela cell Amount of lysate: 60ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 15 minutes)
Application Data
(Gel: 12%SDS-PAGE Lysates (from left to right): Human fetal liver tissue and hela cell Amount of lysate: 60ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 15 minutes)
Related Product Information for anti-GCH1 antibody
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Product Categories/Family for anti-GCH1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,775 Da
NCBI Official Full Name
GTP cyclohydrolase 1 isoform 1
NCBI Official Synonym Full Names
GTP cyclohydrolase 1
NCBI Official Symbol
GCH1
NCBI Official Synonym Symbols
GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1
NCBI Protein Information
GTP cyclohydrolase 1
UniProt Protein Name
GTP cyclohydrolase 1
UniProt Gene Name
GCH1
UniProt Synonym Gene Names
DYT5; GCH; GTP-CH-I
UniProt Entry Name
GCH1_HUMAN
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Product Notes
The GCH1 gch1 (Catalog #AAA305571) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GCH1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GCH1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the GCH1 gch1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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