Rabbit GPVI Polyclonal Antibody | anti-GP6 antibody

GPVI Antibody

Cat. Num. AAA39930

• Gene Names: GP6; GPIV; GPVI; BDPLT11
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: GPVI Antibody is affinity chromatography purified via peptide column.
• Synonyms: GPVI, Antibody; GPVI Antibody; GPVI; GPIV; BDPLT11; Platelet glycoprotein VI; Glycoprotein 6; glycoprotein VI (platelet); anti-GP6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: GPVI Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 339

• Applicable Applications for anti-GP6 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: GPVI antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human GPVI.
• Buffer: GPVI Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: GPVI antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

WB (Western Blot)

(Western blot analysis of GPVI in HeLa (A) and Jurkat (B) with GPVI antibody at 1 μg/mL.)

IF (Immunofluorescence)

(Immunofluorescence of GPVI in Human Heart tissue with GPVI antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of GPVI in K562 cell lysate with GPVI antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-GP6 antibody

GPVI Antibody: Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.

NCBI and Uniprot Product Information

• NCBI GI #: 143770755
• NCBI GeneID: 51206
• NCBI Accession #: NP_057447
• NCBI GenBank Nucleotide #: NM_016363.4
• UniProt Accession #: Q9HCN6; Q9HCN7; Q9UIF2
• Molecular Weight: 67,476 Da
• NCBI Official Full Name: platelet glycoprotein VI isoform 2
• NCBI Official Synonym Full Names: glycoprotein VI (platelet)
• NCBI Official Symbol: GP6
• NCBI Official Synonym Symbols: GPIV; GPVI; BDPLT11
• NCBI Protein Information: platelet glycoprotein VI; glycoprotein 6; platelet collagen receptor
• UniProt Protein Name: Platelet glycoprotein VI
• UniProt Gene Name: GP6
• UniProt Synonym Gene Names: GPVI
• UniProt Entry Name: GPVI_HUMAN