IHC (Immunohiostchemistry)
(Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 ug/mL.)
Rabbit GPVI Polyclonal Antibody | anti-GPVI antibody
GPVI Antibody
Gene Names
GP6; GPIV; GPVI; BDPLT11
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
GPVI, Antibody; GPVI Antibody; Glycoprotein VI, GPIV, Platelet glycoprotein VI precursor; anti-GPVI antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
339
Applicable Applications for anti-GPVI antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 15 amino acid peptide near the carboxy terminus of the human GPVI.
Target Name
GPVI
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 ug/mL.)
WB (Western Blot)
(Western blot analysis of GPVI in A20 lysate with GPVI antibody at 1ug/mL in either the absence or (B) the presence of blocking peptide.)
WB (Western Blot)
(Western blot analysis of GPVI in A20 lysate with GPVI antibody at 1ug/mL in either the absence or (B) the presence of blocking peptide.)
Related Product Information for anti-GPVI antibody
Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.
Product Categories/Family for anti-GPVI antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
67,476 Da
NCBI Official Full Name
platelet glycoprotein VI isoform 2
NCBI Official Synonym Full Names
glycoprotein VI (platelet)
NCBI Official Symbol
GP6
NCBI Official Synonym Symbols
GPIV; GPVI; BDPLT11
NCBI Protein Information
platelet glycoprotein VI
UniProt Protein Name
Platelet glycoprotein VI
UniProt Gene Name
GP6
UniProt Synonym Gene Names
GPVI
UniProt Entry Name
GPVI_HUMAN
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Product Notes
The GPVI gp6 (Catalog #AAA302976) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GPVI Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GPVI can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the GPVI gp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPVI, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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