Rabbit anti-Human GRB10 Polyclonal Antibody | anti-GRB10 antibody

Rabbit anti-GRB10 Antibody, Affinity Purified

Cat. Num. AAA211610

• Gene Names: GRB10; RSS; IRBP; MEG1; GRB-IR; Grb-10
• Reactivity: Human
• Applications: Immunohistochemistry, Immunoprecipitation
• Purity: Antigen Affinity Purified
• Synonyms: GRB10, Antibody; Rabbit anti-GRB10 Antibody, Affinity Purified; maternally expressed gene 1; insulin receptor-binding protein Grb-IR; MEG1; IRBP; GRB-IR; GRB10 adaptor protein; Grb-10; GRB10 adapter protein; growth factor receptor-bound protein 10; RSS; Growth factor receptor-bound protein 10; growth factor receptor bound protein 10; anti-GRB10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
• Concentration: 1000ug/ml (varies by lot)

• Applicable Applications for anti-GRB10 antibody: IHC (Immunohistochemistry), IP (Immunoprecipitation)
• Immunogen: Between 100 and 150
• Conjugation: Unconjugated
• Preparation and Storage: Store at 2-8 degree C; Shelf Life: 1 year from date of receipt

IP (Immunoprecipitation)

(Detection of human GRB10 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-GRB10 antibody AAA211610 used for IP at 3 ug/mg lysate. GRB10 was also immunoprecipitated by rabbit anti-GRB10 antibody which recognizes an upstream epitope. For blotting immunoprecipitated GRB10, was used at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.)

IHC (Immunohistochemistry)

(Detection of human GRB10 by immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-GRB10 (Cat. No. AAA211610 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB)

Related Product Information for anti-GRB10 antibody

Growth factor receptor-bound protein 10 (GRB10) is a member of a family of adaptor proteins that bind to a variety of growth factor receptors to regulate receptor signaling and mediate signals for a variety of processes such as metabolism, growth, apoptosis, and migration. As a dimer, via its BPS (between PH and SH2) and SH2 (src-homology 2) domains, GRB10 associates with the insulin receptor (IR) as well as the insulin-like growth factor receptor (IGFR). GRB10's association with the IR has been shown to have inhibitory effects on insulin-induced kinase signaling; however studies have also reported that GRB10 can also have positive effects on IR signaling. It is suggested that GRB10 can serve in cellular functions independent of an interaction with the IR.

Product Categories/Family for anti-GRB10 antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 48762679
• NCBI GeneID: 2887
• NCBI Accession #: NP_005302.3; NP_001001549.1
• NCBI GenBank Nucleotide #: NM_005311.4
• UniProt Accession #: Q13322; O00427; O00701; O75222; Q92606; Q92907; Q92948; A4D258; A7VJ95; A8K0E6; D3DVM9
• Molecular Weight: 66,487 Da
• NCBI Official Full Name: growth factor receptor-bound protein 10 isoform a
• NCBI Official Synonym Full Names: growth factor receptor bound protein 10
• NCBI Official Symbol: GRB10
• NCBI Official Synonym Symbols: RSS; IRBP; MEG1; GRB-IR; Grb-10
• NCBI Protein Information: growth factor receptor-bound protein 10
• UniProt Protein Name: Growth factor receptor-bound protein 10
• UniProt Gene Name: GRB10
• UniProt Synonym Gene Names: GRBIR; KIAA0207
• UniProt Entry Name: GRB10_HUMAN