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IHC (Immunohistochemistry)
(GREM1/Gremlin-1 Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human GREM1/Gremlin-1 Polyclonal Antibody | anti-GREM1 antibody
GREM1/Gremlin-1 Rabbit anti-Human Polyclonal (aa26-184) Antibody
Gene Names
GREM1; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Synonyms
GREM1/Gremlin-1, Antibody; GREM1/Gremlin-1 Rabbit anti-Human Polyclonal (aa26-184) Antibody; PathPlus GREM1/Gremlin-1 Antibody (aa26-184); GREM1; CKTSF1B1; DAN domain family member 2; DAND2; DRM; GREMLIN; Gremlin 1-like protein; Increased in high glucose-2; Gremlin-1; PIG2; Proliferation-inducing gene 2; Gremlin 1; IHG-2; anti-GREM1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody is a rabbit polyclonal antibody raised against GREM1.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Form/Format
PBS, pH7.4, 0.05% Proclin-300, 50% glycerol
Concentration
0.5mg/ml (varies by lot)
Applicable Applications for anti-GREM1 antibody
WB (Western Blot), IHC (Immunohistochemistry)
Target
Human GREM1/Gremlin-1
Immunogen
Recombinant GREM1 (Lys26-Asp184) expressed in E Coli.
Conjugation
Unconjugated
Epitope
aa26-184
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
IHC (Immunohistochemistry)
(GREM1/Gremlin-1 Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(GREM1/Gremlin-1 Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(GREM1/Gremlin-1 Antibody-Western blot of recombinant GREM1/Gremlin-1.)
WB (Western Blot)
(GREM1/Gremlin-1 Antibody-Western blot of recombinant GREM1/Gremlin-1.)
WB (Western Blot)
(GREM1/Gremlin-1 Antibody-Western Blot; Sample: Recombinant GREM1, Human.)
WB (Western Blot)
(GREM1/Gremlin-1 Antibody-Western Blot; Sample: Recombinant GREM1, Human.)
WB (Western Blot)
(GREM1/Gremlin-1 Antibody-Western Blot; Sample: Rat Intestine Tissue.)
WB (Western Blot)
(GREM1/Gremlin-1 Antibody-Western Blot; Sample: Rat Intestine Tissue.)
Related Product Information for anti-GREM1 antibody
Gremlin-1 antibody is an unconjugated rabbit polyclonal antibody to human Gremlin-1 (GREM1)(aa26-184). Validated for IHC and WB.
GREM1 (Gremlin-1) is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
GREM1 (Gremlin-1) is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16,292 Da
NCBI Official Full Name
gremlin-1 isoform 1
NCBI Official Synonym Full Names
gremlin 1, DAN family BMP antagonist
NCBI Official Symbol
GREM1
NCBI Official Synonym Symbols
DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
NCBI Protein Information
gremlin-1; gremlin 1-like protein; DAN domain family member 2; increased in high glucose-2; colorectal adenoma and carcinoma 1; cell proliferation-inducing gene 2 protein; cysteine knot superfamily 1, BMP antagonist 1; gremlin 1, cysteine knot superfamily
UniProt Protein Name
Gremlin-1
UniProt Gene Name
GREM1
UniProt Synonym Gene Names
CKTSF1B1; DAND2; DRM; IHG-2
UniProt Entry Name
GREM1_HUMAN
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Product Notes
The GREM1 grem1 (Catalog #AAA163110) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GREM1/Gremlin-1 Rabbit anti-Human Polyclonal (aa26-184) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GREM1/Gremlin-1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the GREM1 grem1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GREM1/Gremlin-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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