Rabbit Grik4 Polyclonal Antibody | anti-GRIK4 antibody

Grik4 Antibody

Cat. Num. AAA39302

• Gene Names: GRIK4; KA1; EAA1; GRIK; GluK4
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: Grik4 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Grik4, Antibody; Grik4 Antibody; Grik4; KA1; EAA1; GRIK; GluK4; Glutamate receptor ionotropic; kainate 4; Excitatory amino acid receptor 1; glutamate receptor, ionotropic, kainate 4; anti-GRIK4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Grik4 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 956

• Applicable Applications for anti-GRIK4 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Grik4 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human Grik4.
• Buffer: Grik4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Grik4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of Grik4 in Human Brain cells with Grik4 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemical staining of human brain tissue using Grik4 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of Grik4 in rat brain lysate with Grik4 antibody at (A) 0.5 (B) 1 and (C) 2 μg/mL.)

Related Product Information for anti-GRIK4 antibody

Grik4 Antibody: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.

NCBI and Uniprot Product Information

• NCBI GI #: 209572625
• NCBI GeneID: 2900
• UniProt Accession #: Q16099; A8K9L1
• Molecular Weight: 107,246 Da
• NCBI Official Full Name: Glutamate receptor ionotropic, kainate 4
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, kainate 4
• NCBI Official Symbol: GRIK4
• NCBI Official Synonym Symbols: KA1; EAA1; GRIK; GluK4
• NCBI Protein Information: glutamate receptor ionotropic, kainate 4; glutamate receptor KA1; glutamate receptor KA-1; excitatory amino acid receptor 1
• UniProt Protein Name: Glutamate receptor ionotropic, kainate 4
• UniProt Gene Name: GRIK4
• UniProt Synonym Gene Names: GRIK; GluK4; EAA1; KA1
• UniProt Entry Name: GRIK4_HUMAN