Rabbit GRM1 Polyclonal Antibody | anti-GRM1 antibody

GRM1 Polyclonal Antibody

Cat. Num. AAA169595

• Gene Names: GRM1; MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen affinity purification
• Synonyms: GRM1, Antibody; GRM1 Polyclonal Antibody; GRM1A, mGlu1, GPRC1A, MGLUR1, SCAR13, MGLUR1A; anti-GRM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 0.4mg/mL (varies by lot)
• Sequence Length: 1194

• Applicable Applications for anti-GRM1 antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Synthetic peptide of human GRM1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using GRM1 Polyclonal Antibody at dilution of 1:10)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using GRM1 Polyclonal Antibody at dilution of 1:10)

Related Product Information for anti-GRM1 antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.

Product Categories/Family for anti-GRM1 antibody

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 108752138
• NCBI GeneID: 2911
• Molecular Weight: 101,473 Da
• NCBI Official Full Name: GRM1 protein, partial
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 1
• NCBI Official Symbol: GRM1
• NCBI Official Synonym Symbols: MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85
• NCBI Protein Information: metabotropic glutamate receptor 1; protein phosphatase 1, regulatory subunit 85
• UniProt Protein Name: Metabotropic glutamate receptor 1
• UniProt Gene Name: GRM1
• UniProt Synonym Gene Names: GPRC1A; MGLUR1; mGluR1
• UniProt Entry Name: GRM1_HUMAN