Rabbit anti-Human HEXB Polyclonal Antibody | anti-HEXB antibody

HEXB Rabbit anti-Human Polyclonal Antibody

Cat. Num. AAA163009

• Gene Names: HEXB; ENC-1AS
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity purified
• Synonyms: HEXB, Antibody; HEXB Rabbit anti-Human Polyclonal Antibody; PathPlus HEXB Antibody; HEXB; Beta-hexosanimidase; Beta-N-acetylhexosaminidase; Beta-hexosaminidase beta chain; HCC-7; Hexosaminidase subunit B; N-acetyl-beta- glucosaminidase; ENC-1AS; anti-HEXB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity purified
• Form/Format: PBS, 0.1% Sodium Azide
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-HEXB antibody: IHC (Immunohistochemistry)
• Target: Human HEXB
• Immunogen: LP-10968, synthetic peptide
• Conjugation: Unconjugated
• Preparation and Storage: Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.

IHC (Immunohistochemistry)

(HEXB Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemisry)

(HEXB Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohiostchemistry)

(HEXB Antibody-Human Testis Leydig Cells: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemistry)

(HEXB Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-HEXB antibody

HEXB antibody is an unconjugated rabbit polyclonal antibody to HEXB from human. Validated for IHC.
HEXB (Hexosaminidase B subunit beta) is the beta subunit of the lysosomal enzyme beta-hexosaminidase that catalyzes the degradation of the ganglioside GM2 and other molecules containing terminal N-acetyl hexosamines. Mutations in the alpha or beta subunit genes of beta-hexosaminidase lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II), a lysosomal disorder characterized by progressive neurodegeneration and childhood mortality. In immunohistochemistry of normal tissue, HEXB has cytoplasmic positivity in the lung, epididymis, testes, prostate, heart muscle, some immune tissues, gastrointestinal tissues, endocrine tissues, the kidney, the pancreas and the brain.

References

The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; PLoS One. 2012; 7(7): e41516, PMID: 22848519;

NCBI and Uniprot Product Information

• NCBI GI #: 4504373
• NCBI GeneID: 3074
• NCBI Accession #: NP_000512.1
• NCBI GenBank Nucleotide #: NM_000521
• UniProt Accession #: P07686
• Molecular Weight: 63,111 Da
• NCBI Official Full Name: beta-hexosaminidase subunit beta preproprotein
• NCBI Official Synonym Full Names: hexosaminidase B (beta polypeptide)
• NCBI Official Symbol: HEXB
• NCBI Official Synonym Symbols: ENC-1AS
• NCBI Protein Information: beta-hexosaminidase subunit beta; HCC-7; hexosaminidase subunit B; beta-N-acetylhexosaminidase subunit beta; cervical cancer proto-oncogene 7 protein; N-acetyl-beta-glucosaminidase subunit beta
• UniProt Protein Name: Beta-hexosaminidase subunit beta
• UniProt Gene Name: HEXB
• UniProt Synonym Gene Names: Hexosaminidase subunit B; HCC-7
• UniProt Entry Name: HEXB_HUMAN