Rabbit HMGCR Polyclonal Antibody | anti-HMGCR antibody

HMGCR Antibody

Cat. Num. AAA303991

• Gene Names: HMGCR; LDLCQ3
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Affinity purification
• Synonyms: HMGCR, Antibody; HMGCR Antibody; LDLCQ3; anti-HMGCR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous level of total HMGCR protein.
• Purity/Purification: Affinity purification
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 888

• Applicable Applications for anti-HMGCR antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant fusion protein of human HMGCR (NP_000850.1)
• Target Name: HMGCR
• Preparation and Storage: Store at -20°C

IF (Immunofluorescence)

(Immunofluorescence analysis of U-2 OS cells using HMGCR Rabbit pAb)

IF (Immunofluorescence)

(Immunofluorescence analysis of NIH-3T3 cells using HMGCR Rabbit pAb.)

IF (Immunofluorescence)

(Immunofluorescence analysis of C6 cells using HMGCR Rabbit pAb.)

WB (Western Blot)

(Western blot analysis of extracts of Rat brain, using HMGCR Rabbit pAb)

WB (Western Blot)

(Western blot analysis of extracts of Mouse spleen, using HMGCR Rabbit pAb.)

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded human uterinecancer using HMGCR at dilution of 1:200 (40x lens)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, usingHMGCR at 1:1000 dilution.)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human smallintestine using HMGCR at dilution of 1:200 (40x lens).)

Related Product Information for anti-HMGCR antibody

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-HMGCR antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4557643
• NCBI GeneID: 3156
• NCBI Accession #: NP_000850.1
• NCBI GenBank Nucleotide #: NM_000859.2
• UniProt Accession #: P04035; Q8N190; B7Z3Y9
• Molecular Weight: SDS-PAGE MW: 97 KDa
• NCBI Official Full Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1
• NCBI Official Synonym Full Names: 3-hydroxy-3-methylglutaryl-CoA reductase
• NCBI Official Symbol: HMGCR
• NCBI Official Synonym Symbols: LDLCQ3
• NCBI Protein Information: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
• UniProt Protein Name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
• UniProt Gene Name: HMGCR
• UniProt Synonym Gene Names: HMG-CoA reductase
• UniProt Entry Name: HMDH_HUMAN