WB (Western Blot)
(Host: RabbitTarget Name: HMGCRSample Tissue: Human PANC1Whole Cell lysatesAntibody Dilution: 1ug/ml)
Rabbit anti-Human HMGCR Polyclonal Antibody | anti-HMGCR antibody
HMGCR Antibody - middle region
Gene Names
HMGCR; LDLCQ3
Reactivity
Human
Applications
Western Blot
Purity
Affinity purified
Synonyms
HMGCR, Antibody; HMGCR Antibody - middle region; anti-HMGCR antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Sequence
Synthetic peptide located within the following region: TLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIG
Sequence Length
888
Applicable Applications for anti-HMGCR antibody
WB (Western Blot)
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human HMGCR
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(Host: RabbitTarget Name: HMGCRSample Tissue: Human PANC1Whole Cell lysatesAntibody Dilution: 1ug/ml)
WB (Western Blot)
(Host: RabbitTarget Name: HMGCRSample Tissue: Human PANC1Whole Cell lysatesAntibody Dilution: 1ug/ml)
WB (Western Blot)
(Host: MouseTarget Name: HMGCRSample Tissue: Mouse PancreasAntibody Dilution: 1ug/ml)
WB (Western Blot)
(Host: MouseTarget Name: HMGCRSample Tissue: Mouse PancreasAntibody Dilution: 1ug/ml)
Related Product Information for anti-HMGCR antibody
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-HMGCR antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
98 kDa
NCBI Official Full Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA reductase
NCBI Official Symbol
HMGCR
NCBI Official Synonym Symbols
LDLCQ3
NCBI Protein Information
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
UniProt Protein Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt Gene Name
HMGCR
UniProt Synonym Gene Names
HMG-CoA reductase
UniProt Entry Name
HMDH_HUMAN
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Product Notes
The HMGCR hmgcr (Catalog #AAA201564) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HMGCR Antibody - middle region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HMGCR can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the HMGCR hmgcr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: TLMETHERGV SIRRQLLSKK LSEPSSLQYL PYRDYNYSLV MGACCENVIG. It is sometimes possible for the material contained within the vial of "HMGCR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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