Rabbit HSP90 alpha Polyclonal Antibody | anti-HSP86; Heat shock protein 90 alpha antibody

HSP90 alpha polyclonal antibody

Cat. Num. AAA76998

• Gene Names: Hsp90aa1; hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1; AL024080; AL024147
• Reactivity: Human, Mouse, Rat, Beluga, Bovine, Dog, Fish, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus
• Applications: Western Blot, Immunohistochemistry
• Purity: Protein A affinity purified.
• Synonyms: HSP90 alpha, Antibody; HSP90 alpha polyclonal antibody; HSP90 alpha; anti-HSP86; Heat shock protein 90 alpha antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Beluga, Bovine, Dog, Fish, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus
• Clonality: Polyclonal
• Specificity: Recognizes human, mouse, rat, bovine, beluga, dog, fish, guinea pig, hamster, monkey, pig, rabbit, sheep and Xenopus HSP90 alpha. Detects a band of ~90kDa by Western blot.
• Purity/Purification: Protein A affinity purified.
• Form/Format: Liquid. In PBS containing 0.09% sodium azide and 50% glycerol.
• Sequence Length: 733

• Applicable Applications for anti-HSP86; Heat shock protein 90 alpha antibody: IA (Inhibition Assay), WB (Western Blot), IHC (Immunohistochemistry)
• Immunogen: Synthetic peptide corresponding to a portion of mouse Hsp86.
• Source: Purified from rabbit serum.
• Preparation and Storage: Long term storage: -20 degree C; Avoid freeze/thaw cycles.

WB (Western Blot)

(Western blot analysis of HSP90α, pAb : Lane 1: MW Marker, Lane 2: HeLa Cell Lysate (heat shocked), Lane 3: PC-12 Cell Lysate (heat shocked), Lane 4: 3T3 Cell Lysate (heat shocked), Lane 5: CHO-K1 Cell Lysate (heat shocked), Lane 6: MDBK Cell Lysate (heat shocked), Lane 7: MDCK Cell Lysate (heat shocked), Lane 8: Vero Cell Lysate (heat shocked), Lane 9: RK-13 Cell Lysate (heat shocked))

Related Product Information for anti-HSP86; Heat shock protein 90 alpha antibody

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Product Categories/Family for anti-HSP86; Heat shock protein 90 alpha antibody

Protein Synthesis & Folding; Proteolysis & Protein Degradation; Cell Death

NCBI and Uniprot Product Information

• NCBI GI #: 1170384
• NCBI GeneID: 15519
• UniProt Accession #: P07901
• NCBI Official Full Name: Heat shock protein HSP 90-alpha
• NCBI Official Synonym Full Names: heat shock protein 90, alpha (cytosolic), class A member 1
• NCBI Official Symbol: Hsp90aa1
• NCBI Official Synonym Symbols: hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1; AL024080; AL024147
• NCBI Protein Information: heat shock protein HSP 90-alpha
• UniProt Protein Name: Heat shock protein HSP 90-alpha
• UniProt Gene Name: Hsp90aa1
• UniProt Synonym Gene Names: Hsp86; Hsp86-1; Hspca; HSP 86; HSP86; TSTA
• UniProt Entry Name: HS90A_MOUSE