WB (Western Blot)
(HTR1B antibody (AAA107388) used at 5 ug/ml to detect target protein.)
Rabbit HTR1B Polyclonal Antibody | anti-HTR1B antibody
HTR1B antibody
Gene Names
HTR1B; S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB
Applications
Western Blot
Synonyms
HTR1B, Antibody; HTR1B antibody; Polyclonal HTR1B; Anti-HTR1B; HTRB-1; HTR1B; 5-hydroxytryptamine; HTRB 1; serotonin receptor 1B; anti-HTR1B antibody
Host
Rabbit
Clonality
Polyclonal
Form/Format
Purified antibody supplied as a liquid in PBS buffer with 0.09% NaN3, and 2% Sucrose.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
390
Applicable Applications for anti-HTR1B antibody
WB (Western Blot)
Biological Significance
The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Cross-Reactivity
Human
Immunogen
Synthetic peptide directed toward the N terminal region of human HTR1B.
Preparation and Storage
4°C short term, -20C long term. Avoid repeat freeze-thaws.
WB (Western Blot)
(HTR1B antibody (AAA107388) used at 5 ug/ml to detect target protein.)
WB (Western Blot)
(HTR1B antibody (AAA107388) used at 5 ug/ml to detect target protein.)
Product Categories/Family for anti-HTR1B antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
5-hydroxytryptamine receptor 1B
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
NCBI Official Symbol
HTR1B
NCBI Official Synonym Symbols
S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB
NCBI Protein Information
5-hydroxytryptamine receptor 1B
UniProt Protein Name
5-hydroxytryptamine receptor 1B
UniProt Gene Name
HTR1B
UniProt Synonym Gene Names
HTR1DB; 5-HT-1B; 5-HT1B; 5-HT-1D-beta
UniProt Entry Name
5HT1B_HUMAN
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Product Notes
The HTR1B htr1b (Catalog #AAA107388) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's HTR1B can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the HTR1B htr1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HTR1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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