Rabbit anti-Mouse, Rat IGF1 Polyclonal Antibody | anti-IGF1 antibody

Anti-IGF1 Antibody, Rabbit Polyclonal

Cat. Num. AAA254905

• Gene Names: Igf1; Igf-1; Igf-I; C730016P09Rik
• Reactivity: Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: IGF1, Antibody; Anti-IGF1 Antibody, Rabbit Polyclonal; IGF1 Antibody, Rabbit PAb, Antigen Affinity Purified; insulin-like growth factor 1 (somatomedin C); Anti-C730016P09Rik Antibody; Anti-Igf-1 Antibody; Anti-Igf-I Antibody; anti-IGF1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse IGF1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-IGF1 antibody: IHC (Immunohistochemistry)
• Immunogen: A synthetic peptide corresponding to the center region of the Mouse IGF1
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse IGF1, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

IHC (Immunohistochemisry)

(Immunochemical staining Igf1 in rat liver with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohiostchemistry)

(Immunochemical staining Igf1 in mouse colon with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining Igf1 in mouse liver with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-IGF1 antibody

IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II (IGF-I and IGF-II), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1/IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1/IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1/IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.

Product Categories/Family for anti-IGF1 antibody

Serine Proteases and Regulators

References

Jansen M., et al., (1983), Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306:609-611.de Pagter-Holthuizen P., et al., (1986), Organization of the human genes for insulin-like growth factors I and II.FEBS Lett. 195:179-184.le Bouc Y., et al., (1986), Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.FEBS Lett. 196:108-112.

NCBI and Uniprot Product Information

• NCBI GI #: 163659894
• NCBI GeneID: 16000
• NCBI Accession #: NP_001104745.1
• NCBI GenBank Nucleotide #: NM_001111275.1
• UniProt Accession #: P05017; P05018; Q6LDP4; Q8C4U6
• Molecular Weight: 17,623 Da
• NCBI Official Full Name: insulin-like growth factor I isoform 4 preproprotein
• NCBI Official Synonym Full Names: insulin-like growth factor 1
• NCBI Official Symbol: Igf1
• NCBI Official Synonym Symbols: Igf-1; Igf-I; C730016P09Rik
• NCBI Protein Information: insulin-like growth factor I; somatomedin
• UniProt Protein Name: Insulin-like growth factor I
• UniProt Gene Name: Igf1
• UniProt Synonym Gene Names: Igf-1; IGF-I
• UniProt Entry Name: IGF1_MOUSE