Rabbit IkBalpha Polyclonal Antibody | anti-IkBalpha antibody
IkB-alpha (C21) Antibody
Synonyms
IkBalpha, Antibody; IkB-alpha (C21) Antibody; anti-IkBalpha antibody
Host
Rabbit
Clonality
Polyclonal
Specificity
IkB-a (C21) is recommmended to detect mouse, rat and human IkB-a by western blotting, immunoprecipitation, and immunohistochemistry
(including paraffin-embedded tissue).
Form/Format
Each vial contains 200 ug/mL of affinity purified rabbit IgG , IkB-a (C21) DB075, in 1 mL PBS containing 0.1% sodium azide and 0.2% gelatin.
Origin
IkB-alpha (C21) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminal domain of human IkB-alpha.
Competition studies
A blocking peptide is also available. DB075P, for use in competition studies. Each vial contains 100 ug of peptide in 0.5 mL PBS with 0.1% sodium azide and 100 ug BSA.
Preparation and Storage
Store this product at 4°C, do not freeze. The product is stable for one year from the date of shipment.
Related Product Information for anti-IkBalpha antibody
The NFkB family of transcription factors is sequestered in the cytoplasm by IkB inhibitory proteins (1&2).IkB-alpha and IkB-beta are the two members of this family most often cited for their regulatory function of NFkB directed gene expression. The interaction of NFkB dimers with IkB proteins keeps the complex in the cytoplasm, but upon cellular stimulation the IkB proteins are phosphorylated and subsequently degraded (1&3). The free NFkB can now enter the nucleus and induce gene expression of proteins critical for cellular proliferation, differentation, or apoptosis (1-4).
References
1. Schmitz ML, Baeuerle PA. 1995. Multi-step activation of NF-kappa B/Rel transcription factors. Immunobiology 193(2-4):116-127.2. Tran K, Merika M, Thanos D. 1997. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 17(9):5386-5399.3. Tanaka K, Kawakami T, Tateishi K, Yashiroda H, Chiba T. 2001. Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway. Biochimie 83(3-4):351-356.4. Chen CG, Malliaros J, Katerelos M, d?Apice AJ, Pearse MJ. Inhibition of NF-kappaB activation by a dominant-negative mutant of IkappaBalpha. Mol. Immunology 33(1):57-61.
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Product Notes
The IkBalpha (Catalog #AAA63015) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IkBalpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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