Rabbit IL-33 Polyclonal Antibody | anti-IL33 antibody

IL-33 Antibody

Cat. Num. AAA39438

• Gene Names: IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
• Purity: IL-33 Antibody is affinity chromatography purified via peptide column.
• Synonyms: IL-33, Antibody; IL-33 Antibody; IL-33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; NFHEV; Interleukin-33; Interleukin-1 family member 11; interleukin 33; anti-IL33 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: IL-33 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 270

• Applicable Applications for anti-IL33 antibody: IHC (Immunohistochemistry), IF (Immunofluorescence), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: IL-33 antibody was raised against a 19 amino acid synthetic peptide from near the center of human IL-33.; The immunogen is located within amino acids 150 - 200 of IL-33.
• Buffer: IL-33 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: IL-33 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of IL-33 in Human Lymph Node tissue with IL-33 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of IL-33 in human lymph node tissue with IL-33 antibody at 2.5 μg/ml.)

WB (Western Blot)

(Western blot analysis of IL-33 in A-20 cell lysate with IL-33 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-IL33 antibody

IL-33 Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1α/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.

NCBI and Uniprot Product Information

• NCBI GI #: 15559209
• NCBI GeneID: 90865
• NCBI Accession #: NP_254274
• NCBI GenBank Nucleotide #: NM_033439.3
• UniProt Accession #: O95760; Q2YEJ5; B2R8L1; B4DJ35; B4E1Q9; D3DRI5; E7EAX4
• Molecular Weight: Predicted: 30 kDa; ; Observed: 36 kDa
• NCBI Official Full Name: interleukin-33 isoform 1
• NCBI Official Synonym Full Names: interleukin 33
• NCBI Official Symbol: IL33
• NCBI Official Synonym Symbols: DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
• NCBI Protein Information: interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules
• UniProt Protein Name: Interleukin-33
• UniProt Gene Name: IL33
• UniProt Synonym Gene Names: C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV
• UniProt Entry Name: IL33_HUMAN