Rabbit Integrin alpha 4 Polyclonal Antibody | anti-ITGA4 antibody

Integrin alpha 4 Antibody

Cat. Num. AAA39944

• Gene Names: ITGA4; IA4; CD49D
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Western Blot, ELISA
• Purity: Integrin alpha 4 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Integrin alpha 4, Antibody; Integrin alpha 4 Antibody; Integrin alpha 4; IA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); anti-ITGA4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Integrin alpha 4 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1032

• Applicable Applications for anti-ITGA4 antibody: IF (Immunofluorescence), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Integrin alpha 4 antibody was raised against a 16 amino acid synthetic peptide from near the center of human Integrin alpha 4.
• Buffer: Integrin alpha 4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Integrin alpha 4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of Integrin alpha 4 in Jurkat cells with Integrin alpha 4 antibody at 2 μg/mL.)

WB (Western Blot)

(Western blot analysis of Integrin alpha 4 using (A) 25 and (B) 100 ng of recombinant Integrin alpha 4 with Integrin alpha 4 antibody at 1 μg/mL.)

Related Product Information for anti-ITGA4 antibody

Integrin alpha 4 Antibody: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta1, the gut mucosal homing receptor for peripheral T cells. At least two isoforms are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 67191027
• NCBI GeneID: 3676
• NCBI Accession #: NP_000876
• NCBI GenBank Nucleotide #: NM_000885.4
• UniProt Accession #: P13612; Q7Z4L6; D3DPG4; AAB25486
• Molecular Weight: 21,536 Da
• NCBI Official Full Name: integrin alpha-4
• NCBI Official Synonym Full Names: integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
• NCBI Official Symbol: ITGA4
• NCBI Official Synonym Symbols: IA4; CD49D
• NCBI Protein Information: integrin alpha-4; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; very late activation protein 4 receptor, alpha 4 subunit
• UniProt Protein Name: Integrin alpha-4
• UniProt Gene Name: ITGA4
• UniProt Synonym Gene Names: CD49D
• UniProt Entry Name: ITA4_HUMAN