Rabbit anti-Human Ipaf Polyclonal Antibody | anti-NLRC4 antibody

Ipaf Antibody

Cat. Num. AAA40360

• Gene Names: NLRC4; CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: Ipaf Antibody is affinity chromatography purified via peptide column.
• Synonyms: Ipaf, Antibody; Ipaf Antibody; Ipaf; CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; CARD12; CLR2.1; UNQ6189/PRO20215; NLR family CARD domain-containing protein 4; CARD; LRR; and NACHT-containing protein; Clan protein; NLR family, CARD domain containing 4; anti-NLRC4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Ipaf Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1024

• Applicable Applications for anti-NLRC4 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Ipaf antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf.
• Buffer: Ipaf Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Ipaf antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of Ipaf in THP1 cells with Ipaf antibody at 10 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of Ipaf in THP-1 cells with Ipaf antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of Ipaf in human PBL lysate with Ipaf antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) μg/mL, respectively.)

Related Product Information for anti-NLRC4 antibody

Ipaf Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NFκ signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family. Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner. Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.

NCBI and Uniprot Product Information

• NCBI GI #: 40788015
• NCBI GeneID: 58484
• NCBI Accession #: NP_067032
• NCBI GenBank Nucleotide #: NM_021209.4
• UniProt Accession #: Q9NPP4; Q96J81; Q96J82; Q96J83; A8K9F8; B2RBQ3; B3KTF0; D6W580
• Molecular Weight: 110 kDa
• NCBI Official Full Name: NLR family CARD domain-containing protein 4 isoform a
• NCBI Official Synonym Full Names: NLR family, CARD domain containing 4
• NCBI Official Symbol: NLRC4
• NCBI Official Synonym Symbols: CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
• NCBI Protein Information: NLR family CARD domain-containing protein 4; NOD-like receptor C4; ICE-protease activating factor; CARD, LRR, and NACHT-containing protein; caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
• UniProt Protein Name: NLR family CARD domain-containing protein 4
• UniProt Gene Name: NLRC4
• UniProt Synonym Gene Names: CARD12; CLAN; CLAN1; IPAF; Clan protein; Ipaf
• UniProt Entry Name: NLRC4_HUMAN