Rabbit anti-Human ITGB7 Polyclonal Antibody | anti-ITGB7 antibody

ITGB7 Antibody (C-term)

Cat. Num. AAA288545

• Reactivity: Human
• Applications: ELISA, Western Blot
• Synonyms: ITGB7, Antibody; ITGB7 Antibody (C-term); Integrin beta-7; Gut homing receptor beta subunit; ITGB7; anti-ITGB7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This ITGB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the C-terminal region of human ITGB7.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Positions: 737-765
• Sequence Length: 798

• Applicable Applications for anti-ITGB7 antibody: ELISA, WB (Western Blot)
• Antigen Region: 737-765
• Cellular Location: Membrane; Single-pass type I membrane protein.
• Tissue Location: Expressed in a variety of leukocyte lines.
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(ITGB7 Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the ITGB7 antibody detected the ITGB7 protein (arrow).)

Related Product Information for anti-ITGB7 antibody

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin,an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Product Categories/Family for anti-ITGB7 antibody

Signal Transduction

References

Cicala, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(49):20877-20882(2009)
Pentikainen, U., et al. J. Mol. Biol. 393(3):644-657(2009)
Lad, Y., et al. J. Biol. Chem. 283(50):35154-35163(2008)
Monteiro, P., et al. Biochem. Biophys. Res. Commun. 358(2):442-448(2007)
Le Floc'h, A., et al. J. Exp. Med. 204(3):559-570(2007)

NCBI and Uniprot Product Information

• NCBI GI #: 4504777
• NCBI GeneID: 3695
• NCBI Accession #: NP_000880.1
• NCBI GenBank Nucleotide #: NM_000889.2
• UniProt Accession #: P26010; Q9UCP7; Q9UCS7
• Molecular Weight: 86903
• NCBI Official Full Name: integrin beta-7
• NCBI Official Synonym Full Names: integrin, beta 7
• NCBI Official Symbol: ITGB7
• NCBI Protein Information: integrin beta-7
• UniProt Protein Name: Integrin beta-7
• UniProt Gene Name: ITGB7
• UniProt Entry Name: ITB7_HUMAN