IHC (Immunohiostchemistry)
(KCNK18 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNK18 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human KCNK18 Polyclonal Antibody | anti-KCNK18 antibody
KCNK18 Antibody (Center)
Gene Names
KCNK18; TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
KCNK18, Antibody; KCNK18 Antibody (Center); Potassium channel subfamily K member 18; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel; KCNK18; TRESK; TRIK; anti-KCNK18 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This KCNK18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the Central region of human KCNK18.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
168-197
Sequence Length
384
Applicable Applications for anti-KCNK18 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(KCNK18 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNK18 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(KCNK18 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNK18 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(KCNK18 Antibody (Center) western blot analysis in SiHa,U251,MCF-7 cell line lysates (35ug/lane).This demonstrates the KCNK18 antibody detected the KCNK18 protein (arrow).)
WB (Western Blot)
(KCNK18 Antibody (Center) western blot analysis in SiHa,U251,MCF-7 cell line lysates (35ug/lane).This demonstrates the KCNK18 antibody detected the KCNK18 protein (arrow).)
Related Product Information for anti-KCNK18 antibody
Two-pore domain potassium channels, such as KCNK18, give
rise to background, or leak, potassium conductance, and they
regulate diverse cellular functions by adjusting both the resting
membrane potential and excitability. KCNK18 is unique among this
family of potassium channels in that its activity is regulated by
intracellular calcium (summary by Czirjak and Enyedi, 2006 [PubMed
16569637]).
rise to background, or leak, potassium conductance, and they
regulate diverse cellular functions by adjusting both the resting
membrane potential and excitability. KCNK18 is unique among this
family of potassium channels in that its activity is regulated by
intracellular calcium (summary by Czirjak and Enyedi, 2006 [PubMed
16569637]).
Product Categories/Family for anti-KCNK18 antibody
References
Lafreniere, R.G., et al. Nat. Med. 16(10):1157-1160(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Egenberger, B., et al. Biochem. Biophys. Res. Commun. 391(2):1262-1267(2010)
Pottosin, I.I., et al. Pflugers Arch. 456(6):1037-1048(2008)
Czirjak, G., et al. J. Biol. Chem. 283(23):15672-15680(2008)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Egenberger, B., et al. Biochem. Biophys. Res. Commun. 391(2):1262-1267(2010)
Pottosin, I.I., et al. Pflugers Arch. 456(6):1037-1048(2008)
Czirjak, G., et al. J. Biol. Chem. 283(23):15672-15680(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43671
NCBI Official Full Name
potassium channel subfamily K member 18
NCBI Official Synonym Full Names
potassium channel, two pore domain subfamily K, member 18
NCBI Official Symbol
KCNK18
NCBI Official Synonym Symbols
TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2
NCBI Protein Information
potassium channel subfamily K member 18
UniProt Protein Name
Potassium channel subfamily K member 18
UniProt Gene Name
KCNK18
UniProt Synonym Gene Names
TRESK; TRIK
UniProt Entry Name
KCNKI_HUMAN
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Product Notes
The KCNK18 kcnk18 (Catalog #AAA289594) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 168-197. The KCNK18 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KCNK18 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the KCNK18 kcnk18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNK18, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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