Rabbit KV1.1 Polyclonal Antibody | anti-KV1.1 antibody

KV1.1 Polyclonal Antibody

Cat. Num. AAA295132

• Gene Names: KCNA1; EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Synonyms: KV1.1, Antibody; KV1.1 Polyclonal Antibody; KCNA1; Potassium voltage-gated channel subfamily A member 1; Voltage-gated K (+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1; anti-KV1.1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal

• Applicable Applications for anti-KV1.1 antibody: WB (Western Blot)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.)

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.)

Related Product Information for anti-KV1.1 antibody

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg (2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:19307729).

NCBI and Uniprot Product Information

• NCBI GI #: 119395748
• NCBI GeneID: 3736
• NCBI Accession #: NP_000208.2
• NCBI GenBank Nucleotide #: NM_000217.2
• UniProt Accession #: Q09470; Q3MIQ9; A6NM83
• Molecular Weight: 56,466 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
• NCBI Official Symbol: KCNA1
• NCBI Official Synonym Symbols: EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 1; voltage-gated K(+) channel HuKI; voltage-gated potassium channel HBK1; voltage-gated potassium channel subunit Kv1.1
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 1
• UniProt Gene Name: KCNA1
• UniProt Entry Name: KCNA1_HUMAN