IHC (Immunohiostchemistry)
(LAMB1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LAMB1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Mouse LAMB1 Polyclonal Antibody | anti-LAMB1 antibody
LAMB1 Antibody (C-term)
Gene Names
LAMB1; CLM; LIS5
Reactivity
Mouse
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
LAMB1, Antibody; LAMB1 Antibody (C-term); Laminin subunit beta-1; Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; LAMB1; anti-LAMB1 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This LAMB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1691-1720 amino acids from the C-terminal region of human LAMB1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
1691-1720
Sequence Length
1,786
Applicable Applications for anti-LAMB1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(LAMB1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LAMB1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(LAMB1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LAMB1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(LAMB1 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the LAMB1 antibody detected the LAMB1 protein (arrow).)
WB (Western Blot)
(LAMB1 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the LAMB1 antibody detected the LAMB1 protein (arrow).)
Related Product Information for anti-LAMB1 antibody
Laminins, a family of extracellular matrix glycoproteins,
are the major noncollagenous constituent of basement membranes.
They have been implicated in a wide variety of biological processes
including cell adhesion, differentiation, migration, signaling,
neurite outgrowth and metastasis. Laminins are composed of 3 non
identical chains: laminin alpha, beta and gamma (formerly A, B1,
and B2, respectively) and they form a cruciform structure
consisting of 3 short arms, each formed by a different chain, and a
long arm composed of all 3 chains. Each laminin chain is a
multidomain protein encoded by a distinct gene. Several isoforms
of each chain have been described. Different alpha, beta and gamma
chain isomers combine to give rise to different heterotrimeric
laminin isoforms which are designated by Arabic numerals in the
order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is
laminin 1. The biological functions of the different chains and
trimer molecules are largely unknown, but some of the chains have
been shown to differ with respect to their tissue distribution,
presumably reflecting diverse functions in vivo. This gene encodes
the beta chain isoform laminin, beta 1. The beta 1 chain has 7
structurally distinct domains which it shares with other beta chain
isomers. The C-terminal helical region containing domains I and II
are separated by domain alpha, domains III and V contain several
EGF-like repeats, and domains IV and VI have a globular
conformation. Laminin, beta 1 is expressed in most tissues that
produce basement membranes, and is one of the 3 chains constituting
laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm
(EHS) tumor. A sequence in the beta 1 chain that is involved in
cell attachment, chemotaxis, and binding to the laminin receptor
was identified and shown to have the capacity to inhibit
metastasis.
are the major noncollagenous constituent of basement membranes.
They have been implicated in a wide variety of biological processes
including cell adhesion, differentiation, migration, signaling,
neurite outgrowth and metastasis. Laminins are composed of 3 non
identical chains: laminin alpha, beta and gamma (formerly A, B1,
and B2, respectively) and they form a cruciform structure
consisting of 3 short arms, each formed by a different chain, and a
long arm composed of all 3 chains. Each laminin chain is a
multidomain protein encoded by a distinct gene. Several isoforms
of each chain have been described. Different alpha, beta and gamma
chain isomers combine to give rise to different heterotrimeric
laminin isoforms which are designated by Arabic numerals in the
order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is
laminin 1. The biological functions of the different chains and
trimer molecules are largely unknown, but some of the chains have
been shown to differ with respect to their tissue distribution,
presumably reflecting diverse functions in vivo. This gene encodes
the beta chain isoform laminin, beta 1. The beta 1 chain has 7
structurally distinct domains which it shares with other beta chain
isomers. The C-terminal helical region containing domains I and II
are separated by domain alpha, domains III and V contain several
EGF-like repeats, and domains IV and VI have a globular
conformation. Laminin, beta 1 is expressed in most tissues that
produce basement membranes, and is one of the 3 chains constituting
laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm
(EHS) tumor. A sequence in the beta 1 chain that is involved in
cell attachment, chemotaxis, and binding to the laminin receptor
was identified and shown to have the capacity to inhibit
metastasis.
Product Categories/Family for anti-LAMB1 antibody
References
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Rooney, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(19):7991-7996(2009)
Delektorskaya, V.V., et al. Bull. Exp. Biol. Med. 146(5):616-619(2008)
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Rooney, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(19):7991-7996(2009)
Delektorskaya, V.V., et al. Bull. Exp. Biol. Med. 146(5):616-619(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
198038
NCBI Official Full Name
laminin subunit beta-1
NCBI Official Synonym Full Names
laminin, beta 1
NCBI Official Symbol
LAMB1
NCBI Official Synonym Symbols
CLM; LIS5
NCBI Protein Information
laminin subunit beta-1
UniProt Protein Name
Laminin subunit beta-1
UniProt Gene Name
LAMB1
UniProt Entry Name
LAMB1_HUMAN
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Product Notes
The LAMB1 lamb1 (Catalog #AAA289599) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1691-1720. The LAMB1 Antibody (C-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LAMB1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the LAMB1 lamb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAMB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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