WB (Western Blot)
(Anti-LKB1 Picoband antibody, AAA46243, Western blottingAll lanes: Anti LKB1 (AAA46243) at 0.5ug/mlLane 1: 293T Whole Cell Lysate at 40ugLane 2: HT1080 Whole Cell Lysate at 40ugLane 3: SHG Whole Cell Lysate at 40ugLane 4: JURKAT Whole Cell Lysate at 40ugLane 5: Human Placenta Tissue Lysate at 50ugPredicted bind size: 48KDObserved bind size: 60KD)
anti-Human LKB1 Polyclonal Antibody | anti-LKB1 antibody
Anti-LKB1 Antibody
Gene Names
STK11; PJS; LKB1; hLKB1
Reactivity
Human
Applications
Western Blot
Purity
Immunogen Affinity Purified
Synonyms
LKB1, Antibody; Anti-LKB1 Antibody; Serine/threonine-protein kinase STK11; hLKB1; Liver kinase B1; LKB 1; LKB1; NY REN 19 antigen; Peutz Jeghers syndrome; PJS; Polarization related protein LKB1; Renal carcinoma antigen NY-REN-19; Serine/Threonine Kinase 11; Serine/threonine protein kinase 11; Serine/threonine protein kinase LKB1; Serine/threonine protein kinase STK11; Serine/threonine-protein kinase 11; Serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase XEEK1; STK 11; STK11; STK11_HUMAN; serine/threonine kinase 11; anti-LKB1 antibody
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
433
Applicable Applications for anti-LKB1 antibody
WB (Western Blot)
Immunogen
E Coli-derived human LKB1 recombinant protein (Position: K62-C430). Human LKB1 shares 89% amino acid (aa) sequence identity with both mouse and rat LKB1.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Anti-LKB1 Picoband antibody, AAA46243, Western blottingAll lanes: Anti LKB1 (AAA46243) at 0.5ug/mlLane 1: 293T Whole Cell Lysate at 40ugLane 2: HT1080 Whole Cell Lysate at 40ugLane 3: SHG Whole Cell Lysate at 40ugLane 4: JURKAT Whole Cell Lysate at 40ugLane 5: Human Placenta Tissue Lysate at 50ugPredicted bind size: 48KDObserved bind size: 60KD)
WB (Western Blot)
(Anti-LKB1 Picoband antibody, AAA46243, Western blottingAll lanes: Anti LKB1 (AAA46243) at 0.5ug/mlLane 1: 293T Whole Cell Lysate at 40ugLane 2: HT1080 Whole Cell Lysate at 40ugLane 3: SHG Whole Cell Lysate at 40ugLane 4: JURKAT Whole Cell Lysate at 40ugLane 5: Human Placenta Tissue Lysate at 50ugPredicted bind size: 48KDObserved bind size: 60KD)
WB (Western Blot)
(Anti-LKB1 Picoband antibody, AAA46243, Western blottingAll lanes: Anti LKB1 (AAA46243) at 0.5ug/mlWB: Recombinant Human LKB1 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD)
WB (Western Blot)
(Anti-LKB1 Picoband antibody, AAA46243, Western blottingAll lanes: Anti LKB1 (AAA46243) at 0.5ug/mlWB: Recombinant Human LKB1 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD)
Related Product Information for anti-LKB1 antibody
Description: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase STK11(STK11) detection. Tested with WB in Human.
Background: Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor. STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. The STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction.
Background: Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor. STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. The STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction.
References
1. Brown KA, McInnes KJ, Takagi K, Ono K, Hunger NI, Wang L, Sasano H, Simpson ER (November 2011). "LKB1 expression is inhibited by estradiol-17beta in MCF-7 cells". J. Steroid Biochem. Mol. Biol. 127 (3-5): 439-43. 2. Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M (January 1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase".
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
45,387 Da
NCBI Official Full Name
serine/threonine-protein kinase STK11
NCBI Official Synonym Full Names
serine/threonine kinase 11
NCBI Official Symbol
STK11
NCBI Official Synonym Symbols
PJS; LKB1; hLKB1
NCBI Protein Information
serine/threonine-protein kinase STK11
UniProt Protein Name
Serine/threonine-protein kinase STK11
UniProt Gene Name
STK11
UniProt Synonym Gene Names
LKB1; PJS; LKB1; hLKB1
UniProt Entry Name
STK11_HUMAN
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Product Notes
The LKB1 stk11 (Catalog #AAA46243) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-LKB1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LKB1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the LKB1 stk11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LKB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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