Rabbit anti-Human, Mouse MALT1 Polyclonal Antibody | anti-MALT1 antibody

MALT1 Polyclonal Antibody

Cat. Num. AAA36927

• Gene Names: MALT1; MLT; MLT1; IMD12
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Affinity Purification
• Synonyms: MALT1, Antibody; MALT1 Polyclonal Antibody; DKFZp434L132; MLT; MLT1; anti-MALT1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 824

• Applicable Applications for anti-MALT1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Species: Human
• Immunogen: Recombinant Protein
• Immunogen: Recombinant protein of human MALT1
• Calculated Molecular Weight: 92kDa
• Preparation and Storage: Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.; Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

IF (Immunofluorescence)

(Immunofluorescence analysis of U2OS cells using MALT1 antibody. Blue: DAPI for nuclear staining.)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using MALT1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.)

Related Product Information for anti-MALT1 antibody

Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-kappaB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-kappaB, resulting in increased proliferation and inhibition of apoptosis (5,6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1 (1,2). The API2-MALT1 fusion protein likely leads to deregulation of NF-kappaB, contributing to increased oncogenic potential (7).

Product Categories/Family for anti-MALT1 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 20455075
• NCBI GeneID: 10892
• UniProt Accession #: Q9UDY8; Q9NTB7; Q9ULX4
• Molecular Weight: 824
• NCBI Official Full Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1
• NCBI Official Synonym Full Names: MALT1 paracaspase
• NCBI Official Symbol: MALT1
• NCBI Official Synonym Symbols: MLT; MLT1; IMD12
• NCBI Protein Information: mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; MALT1 protease; caspase-like protein; MALT lymphoma-associated translocation; mucosa associated lymphoid tissue lymphoma translocation gene 1
• UniProt Protein Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1
• UniProt Gene Name: MALT1
• UniProt Synonym Gene Names: MLT
• UniProt Entry Name: MALT1_HUMAN