IHC (Immunohiostchemistry)
Chicken MAPK12 Polyclonal Antibody | anti-MAPK12 antibody
MAPK12 Antibody
Gene Names
MAPK12; ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunoprecipitation, Immunohistochemistry, ELISA
Purity
Affinity Purified
Synonyms
MAPK12, Antibody; MAPK12 Antibody; Affinity Purified Mitogen-activated protein kinase 12 Antibody; ERK 3 antibody; ERK 5 antibody; ERK 6 antibody=Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein kinase 3 antibody; P38 GAMMA antibody; PRKM12 antibody; SAPK 3 antibody; Stress Activated Protein Kinase 3 antibody; anti-MAPK12 antibody
Host
Chicken
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgY
Purity/Purification
Affinity Purified
Concentration
0.5 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
357
Applicable Applications for anti-MAPK12 antibody
WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), ELISA
Immunogen
Synthetic peptide taken within amino acid region 310-360 on human Mitogen-activated protein kinase 12.
Conjugation
Unconjugated
Molecular Function
Kinase; Serine/threonine-protein kinase; Transferase
Subcellular Location
Cytoplasm; Mitochondrion; Nucleus
Preparation and Storage
Store at -20 degree C for long term storage.
IHC (Immunohiostchemistry)
IHC (Immunohiostchemistry)
IHC (Immunohistochemistry)
IHC (Immunohistochemistry)
Related Product Information for anti-MAPK12 antibody
Overview: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
Structure: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Expression: Highly expressed in skeletal muscle and heart.
Structure: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Expression: Highly expressed in skeletal muscle and heart.
Product Categories/Family for anti-MAPK12 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40,808 Da
NCBI Official Full Name
mitogen-activated protein kinase 12 isoform 2
NCBI Official Synonym Full Names
mitogen-activated protein kinase 12
NCBI Official Symbol
MAPK12
NCBI Official Synonym Symbols
ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA
NCBI Protein Information
mitogen-activated protein kinase 12
UniProt Protein Name
Mitogen-activated protein kinase 12
UniProt Gene Name
MAPK12
UniProt Synonym Gene Names
ERK6; SAPK3; MAP kinase 12; MAPK 12; ERK-6; MAP kinase p38 gamma
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Product Notes
The MAPK12 mapk12 (Catalog #AAA226363) is an Antibody produced from Chicken and is intended for research purposes only. The product is available for immediate purchase. The MAPK12 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MAPK12 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the MAPK12 mapk12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAPK12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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