WB (Western Blot)
(MARCH11 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the 40613 antibody detected the 40613 protein (arrow).)
Rabbit MARCH11 Polyclonal Antibody | anti-MARCH11 antibody
MARCH11 Antibody (C-term)
Gene Names
MARCH11; MARCH-XI
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
MARCH11, Antibody; MARCH11 Antibody (C-term); E3 ubiquitin-protein ligase MARCH11; 632-; Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI; MARCH-XI; MARCH11; anti-MARCH11 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This MARCH11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human MARCH11.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
308-337
Applicable Applications for anti-MARCH11 antibody
ELISA, WB (Western Blot)
Function
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of athioester and then directly transfer theubiquitin to targeted substrates. May play arole in ubuquitin-dependent protein sorting indevelopmenting spermatids.
Cellular Location
Cytoplasmic vesicle membrane{ECO:0000250|UniProtKB:A6P320};Multi-pass membrane protein{ECO:0000250|UniProtKB:A6P320}
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 Weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(MARCH11 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the 40613 antibody detected the 40613 protein (arrow).)
WB (Western Blot)
(MARCH11 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the 40613 antibody detected the 40613 protein (arrow).)
Related Product Information for anti-MARCH11 antibody
MARCH11 is a member of the MARCH family of membrane-bound
E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin
(see MIM 191339) to target lysines in substrate proteins, thereby
signaling their intracellular transport. March11 appears to have a
role in ubiquitin-mediated protein sorting in the trans-Golgi
network (TGN)-multivesicular body (MVB) transport pathway (Morokuma
et al., 2007 [PubMed 17604280]).
E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin
(see MIM 191339) to target lysines in substrate proteins, thereby
signaling their intracellular transport. March11 appears to have a
role in ubiquitin-mediated protein sorting in the trans-Golgi
network (TGN)-multivesicular body (MVB) transport pathway (Morokuma
et al., 2007 [PubMed 17604280]).
Product Categories/Family for anti-MARCH11 antibody
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Morokuma, Y., et al. J. Biol. Chem. 282(34):24806-24815(2007)
Morokuma, Y., et al. J. Biol. Chem. 282(34):24806-24815(2007)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43878
NCBI Official Full Name
E3 ubiquitin-protein ligase MARCH11
NCBI Official Synonym Full Names
membrane-associated ring finger (C3HC4) 11
NCBI Official Symbol
MARCH11
NCBI Official Synonym Symbols
MARCH-XI
NCBI Protein Information
E3 ubiquitin-protein ligase MARCH11
UniProt Protein Name
E3 ubiquitin-protein ligase MARCH11
UniProt Gene Name
MARCH11
UniProt Synonym Gene Names
MARCH-XI
UniProt Entry Name
MARHB_HUMAN
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Product Notes
The MARCH11 march11 (Catalog #AAA283978) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 308-337. The MARCH11 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's MARCH11 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the MARCH11 march11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MARCH11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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