IHC (Immunohiostchemistry)
(Immunochemical staining of human MLANA in human skin with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
Rabbit anti-Human MART-1/MLANA Polyclonal Antibody | anti-MLANA antibody
Anti-MART-1/MLANA Antibody, Rabbit Polyclonal
Gene Names
MLANA; MART1; MART-1
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
MART-1/MLANA, Antibody; Anti-MART-1/MLANA Antibody, Rabbit Polyclonal; MLANA Antibody, Rabbit PAb, Antigen Affinity Purified; melan-A; Anti-MART-1 Antibody; Anti-MART1 Antibody; anti-MLANA antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human MLANA
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-MLANA antibody
IHC (Immunohistochemistry)
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human MLANA
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human MLANA, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Immunochemical staining of human MLANA in human skin with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
IHC (Immunohiostchemistry)
(Immunochemical staining of human MLANA in human skin with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
IHC (Immunohistochemistry)
(Immunochemical staining of human MLANA in human breast carcinoma with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
IHC (Immunohistochemistry)
(Immunochemical staining of human MLANA in human breast carcinoma with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-MLANA antibody
MART-1 is a hydrophobic transmembrane protein without glycosylation sites highly enriched in early melanosomes. MART-1 is necessary for gp1 function, another antigen associated with cutaneous melanoma, involved in the regulation of melanosome formation. MART-1 is expressed in skin and retinae melanocytes and the majority of melanoma tumors, but it is absent from other tissues and tumors. It was isolated thanks to the specific recognition by T lymphocytes of MART-1 derived peptides, especially in the context of the HLA-A21 haplotype, present in tumor infiltrates from melanoma patients. Thus, MART-1 is immunogenic in humans and has been widely exploited to induce anti-melanoma immunity in patients through several vaccination strategies.
References
Barrio MM, Abes R, Colombo M, et al. Human Macrophages and Dendritic Cells Can Equally Present MART-1 Antigen to CD8+ T Cells after Phagocytosis of Gamma-Irradiated Melanoma Cells. Chatenoud L, ed. PLoS ONE. 2012;7(7):e40311.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
13,157 Da
NCBI Official Full Name
melanoma antigen recognized by T-cells 1
NCBI Official Synonym Full Names
melan-A
NCBI Official Symbol
MLANA
NCBI Official Synonym Symbols
MART1; MART-1
NCBI Protein Information
melanoma antigen recognized by T-cells 1; antigen LB39-AA; antigen SK29-AA; protein Melan-A
UniProt Protein Name
Melanoma antigen recognized by T-cells 1
UniProt Gene Name
MLANA
UniProt Synonym Gene Names
MART1; MART-1
UniProt Entry Name
MAR1_HUMAN
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Product Notes
The MLANA mlana (Catalog #AAA254742) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MART-1/MLANA Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MART-1/MLANA can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the MLANA mlana for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MART-1/MLANA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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