Rabbit anti-Human MAX Polyclonal Antibody | anti-MAX antibody

MAX(Phospho-Ser11) antibody

Cat. Num. AAA307080

• Gene Names: MAX; bHLHd4
• Reactivity: Human
• Applications: Immunofluorescence, Western Blot
• Purity: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Synonyms: MAX, Antibody; MAX(Phospho-Ser11) antibody; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; orf1; anti-MAX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of MAX only when phosphorylated at serine 11.
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 87

• Applicable Applications for anti-MAX antibody: IF (Immunofluorescence), WB (Western Blot)
• Immunogen Type: Peptide
• Immunogen Description: A phospho specific peptide corresponding to residues surrounding S11 of human MAX.
• Modification: Phospho-Ser11
• Target Name: MAX
• Preparation and Storage: Store at -20 degree C

WB (Western Blot)

(Western blot analysis of extracts of Jurkat cell line, using Phospho-MAX-S11 antibody.)

IF (Immunofluorescence)

(Immunofluorescence analysis of U2OS cell using Phospho-MAX-S11 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-MAX antibody

Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis (1). These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription (2). Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families (1). The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior (1). The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription (3,4).

Product Categories/Family for anti-MAX antibody

Phospho-specific Ab

NCBI and Uniprot Product Information

• NCBI GI #: 402794193
• NCBI GeneID: 4149
• NCBI Accession #: NP_001257997.1
• NCBI GenBank Nucleotide #: NM_001271068.1
• UniProt Accession #: P61244; P25912; P52163; Q14803; Q96CY8; A6NH73; A8K265; A8K4G4; A8K824
• Molecular Weight: 9,599 Da
• NCBI Official Full Name: protein max isoform g
• NCBI Official Synonym Full Names: MYC associated factor X
• NCBI Official Symbol: MAX
• NCBI Official Synonym Symbols: bHLHd4
• NCBI Protein Information: protein max
• UniProt Protein Name: Protein max
• UniProt Gene Name: MAX
• UniProt Synonym Gene Names: BHLHD4; bHLHd4
• UniProt Entry Name: MAX_HUMAN