ICC (Immunocytochemistry)
(Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 μg/mL.)
Rabbit anti-Human Mcl-1 Polyclonal Antibody | anti-MCL1 antibody
Mcl-1 Antibody
Gene Names
MCL1; TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
Reactivity
Human
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Mcl-1 Antibody is Ion exchange chromatography purified.
Synonyms
Mcl-1, Antibody; Mcl-1 Antibody; Mcl-1; TM; EAT; MCL1L; MCL1S; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; myeloid cell leukemia sequence 1 (BCL2-related); anti-MCL1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Detects isoforms Mcl-1L and Mcl-1S
Purity/Purification
Mcl-1 Antibody is Ion exchange chromatography purified.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
350
Applicable Applications for anti-MCL1 antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the center of human Mcl-1.
Buffer
Mcl-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
Mcl-1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ICC (Immunocytochemistry)
(Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 μg/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 μg/mL.)
WB (Western Blot)
(Western blot analysis of Mcl-1 in Raji cell lysates with Mcl-1 antibody (IN) at (A) 0.5, (B) 1, and (C) 2 μg/mL.)
WB (Western Blot)
(Western blot analysis of Mcl-1 in Raji cell lysates with Mcl-1 antibody (IN) at (A) 0.5, (B) 1, and (C) 2 μg/mL.)
Related Product Information for anti-MCL1 antibody
Mcl-1 Antibody: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least three distinct isoforms designated Mcl-1L, Mcl-1S and Mcl-1ES. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
28,662 Da
NCBI Official Full Name
induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1
NCBI Official Synonym Full Names
myeloid cell leukemia 1
NCBI Official Symbol
MCL1
NCBI Official Synonym Symbols
TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
NCBI Protein Information
induced myeloid leukemia cell differentiation protein Mcl-1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1; myeloid cell leukemia sequence 1 (BCL2-related)
UniProt Protein Name
Induced myeloid leukemia cell differentiation protein Mcl-1
UniProt Gene Name
MCL1
UniProt Synonym Gene Names
BCL2L3; Bcl2-L-3
UniProt Entry Name
MCL1_HUMAN
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Product Notes
The MCL1 mcl1 (Catalog #AAA40355) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Mcl-1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Mcl-1 can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the MCL1 mcl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mcl-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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