IHC (Immunohiostchemistry)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Mst1/2 (Phospho-Thr183) antibody.)
Rabbit anti-Human, rat Mst1/2 (Phospho-Thr183) Polyclonal Antibody | anti-STK3 antibody
Mst1/2 (Phospho-Thr183) Antibody
Gene Names
STK3; KRS1; MST2
Reactivity
Human, rat
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Mst1/2 (Phospho-Thr183), Antibody; Mst1/2 (Phospho-Thr183) Antibody; Serine/threonine-protein kinase 3; Mammalian STE20-like protein kinase 2; MST-2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1; Serine/threonine-protein kinase 3 36kDa subunit; MST2/N; Serine/threonine-protein kinase 3 20kDa subunit; MST2/C; STK3; KRS1; MST2; anti-STK3 antibody
Host
Rabbit
Reactivity
Human, rat
Clonality
Polyclonal
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
519
Applicable Applications for anti-STK3 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
synthetic peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Mst1/2 (Phospho-Thr183) antibody.)
IHC (Immunohiostchemistry)
(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Mst1/2 (Phospho-Thr183) antibody.)
WB (Western Blot)
(Western blot analysis of extracts from 293 cells, treated with H2O2 (100uM, 15mins), using Mst1/2 (Phospho-Thr183) antibody.)
WB (Western Blot)
(Western blot analysis of extracts from 293 cells, treated with H2O2 (100uM, 15mins), using Mst1/2 (Phospho-Thr183) antibody.)
Related Product Information for anti-STK3 antibody
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
Product Categories/Family for anti-STK3 antibody
References
Creasy C.L.,et al.Gene 167:303-306(1995).
Taylor L.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:10099-10104(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Taylor L.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:10099-10104(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
56301
NCBI Official Full Name
serine/threonine-protein kinase 3 isoform 2
NCBI Official Synonym Full Names
serine/threonine kinase 3
NCBI Official Symbol
STK3
NCBI Official Synonym Symbols
KRS1; MST2
NCBI Protein Information
serine/threonine-protein kinase 3
UniProt Protein Name
Serine/threonine-protein kinase 3
UniProt Gene Name
STK3
UniProt Synonym Gene Names
KRS1; MST2; MST-2; MST2/N; MST2/C
UniProt Entry Name
STK3_HUMAN
Similar Products
Product Notes
The STK3 stk3 (Catalog #AAA286969) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Mst1/2 (Phospho-Thr183) Antibody reacts with Human, rat and may cross-react with other species as described in the data sheet. AAA Biotech's Mst1/2 (Phospho-Thr183) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the STK3 stk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mst1/2 (Phospho-Thr183), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.