Rabbit anti-Human MTBP Polyclonal Antibody | anti-MTBP antibody

MTBP Antibody

Cat. Num. AAA40151

• Gene Names: MTBP; MDM2BP
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: MTBP Antibody is affinity chromatography purified via peptide column.
• Synonyms: MTBP, Antibody; MTBP Antibody; MTBP; MDM2BP; Mdm2-binding protein; hMTBP; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa; anti-MTBP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: MTBP Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 904

• Applicable Applications for anti-MTBP antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: MTBP antibody was raised against a 18 amino acid peptide near the center of human MTBP.
• Buffer: MTBP Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: MTBP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of MTBP in K562 cells with MTBP antibody at 20 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of MTBP in K562 cells with MTBP antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of MTBP expression in K562 cell lysate with MTBP antibody at (A) 1 and (B) 2 μg/ml.)

Related Product Information for anti-MTBP antibody

MTBP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 21630257
• NCBI GeneID: 27085
• NCBI Accession #: NP_071328
• NCBI GenBank Nucleotide #: NM_022045.4
• UniProt Accession #: Q96DY7; Q9HA89; B4DUR5
• Molecular Weight: 104 kDa
• NCBI Official Full Name: mdm2-binding protein
• NCBI Official Synonym Full Names: MDM2 binding protein
• NCBI Official Symbol: MTBP
• NCBI Official Synonym Symbols: MDM2BP
• NCBI Protein Information: mdm2-binding protein; MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa
• UniProt Protein Name: Mdm2-binding protein
• UniProt Gene Name: MTBP
• UniProt Synonym Gene Names: hMTBP
• UniProt Entry Name: MTBP_HUMAN