Rabbit anti-Human NALP1 Polyclonal Antibody | anti-NLRP1 antibody

NALP1 Antibody

Cat. Num. AAA39382

• Gene Names: NLRP1; NAC; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: NALP1 Antibody is immunoaffinity chromatography purified IgG.
• Synonyms: NALP1, Antibody; NALP1 Antibody; NALP1; NAC; CARD7; CIDED; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S; KIAA0926; NACHT; LRR and PYD domains-containing protein 1; Caspase recruitment domain-containing protein 7; NLR family, pyrin domain containing 1; anti-NLRP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: NALP1 Antibody is immunoaffinity chromatography purified IgG.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1429

• Applicable Applications for anti-NLRP1 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: NALP1 antibody was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1.
• Buffer: NALP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: NALP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of NALP1 in K562 cells with NALP1 antibody at 20 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of NALP1 in K562 cells with NALP1 antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of NALP1 in U937 cell lysate with NALP1 antibody at (A) 1, (B) 2 and (C) 4 μg/mL.)

Related Product Information for anti-NLRP1 antibody

NALP1 Antibody: NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1. Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis. NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.

NCBI and Uniprot Product Information

• NCBI GI #: 11096303
• NCBI GeneID: 22861
• UniProt Accession #: Q9C000; Q9BZZ8; Q9BZZ9; Q9H5Z7; Q9H5Z8; Q9HAV8; Q9UFT4; Q9Y2E0; E9PE50; I6L9D9
• Molecular Weight: 46,068 Da
• NCBI Official Full Name: NALP1
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 1
• NCBI Official Symbol: NLRP1
• NCBI Official Synonym Symbols: NAC; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 1; caspase recruitment domain protein 7; NACHT, LRR and PYD containing protein 1; NACHT, leucine rich repeat and PYD containing 1; caspase recruitment domain-containing protein 7; nucleotide-binding domain and caspase recruitment domain; death effector filament-forming Ced-4-like apoptosis protein; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 1
• UniProt Gene Name: NLRP1
• UniProt Synonym Gene Names: CARD7; DEFCAP; KIAA0926; NAC; NALP1
• UniProt Entry Name: NALP1_HUMAN