Rabbit Noxa Polyclonal Antibody | anti-Pmaip1 antibody

Noxa Antibody

Cat. Num. AAA39434

• Gene Names: Pmaip1; Noxa
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: Noxa Antibody is immunoaffinity chromatography purified IgG.
• Synonyms: Noxa, Antibody; Noxa Antibody; Noxa; Phorbol-12-myristate-13-acetate-induced protein 1; phorbol-12-myristate-13-acetate-induced protein 1; anti-Pmaip1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Noxa Antibody is immunoaffinity chromatography purified IgG.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 103

• Applicable Applications for anti-Pmaip1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Noxa antibody was raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.
• Buffer: Noxa Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Noxa antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IHC (Immunohistochemistry)

(Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 μg/mL.)

IF (Immunofluorescence)

(Immunofluorescence of Noxa in Human Stomach cells with Noxa antibody at 10 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of NOXA in human stomach tissue with NOXA antibody at 2.5 μg/ml.)

WB (Western Blot)

(Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.)

Related Product Information for anti-Pmaip1 antibody

Noxa Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.

NCBI and Uniprot Product Information

• NCBI GI #: 10946832
• NCBI GeneID: 58801
• NCBI Accession #: NP_067426
• NCBI GenBank Nucleotide #: NM_021451.2
• UniProt Accession #: Q9JM54
• Molecular Weight: 11,566 Da
• NCBI Official Full Name: phorbol-12-myristate-13-acetate-induced protein 1
• NCBI Official Synonym Full Names: phorbol-12-myristate-13-acetate-induced protein 1
• NCBI Official Symbol: Pmaip1
• NCBI Official Synonym Symbols: Noxa
• NCBI Protein Information: phorbol-12-myristate-13-acetate-induced protein 1; protein Noxa
• UniProt Protein Name: Phorbol-12-myristate-13-acetate-induced protein 1
• UniProt Gene Name: Pmaip1
• UniProt Synonym Gene Names: Noxa
• UniProt Entry Name: APR_MOUSE