IHC (Immunohiostchemistry)
(Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 ug/mL.)
Rabbit Noxa Polyclonal Antibody | anti-Noxa antibody
Noxa Antibody
Gene Names
Pmaip1; Noxa
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Immunoaffinity chromatography purified IgG
Synonyms
Noxa, Antibody; Noxa Antibody; Noxa, PMA-induced protein 1, PMAIP1, APR; anti-Noxa antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Immunoaffinity chromatography purified IgG
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
103
Applicable Applications for anti-Noxa antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.
Target Name
Noxa
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.)
Related Product Information for anti-Noxa antibody
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
Product Categories/Family for anti-Noxa antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
11,566 Da
NCBI Official Full Name
phorbol-12-myristate-13-acetate-induced protein 1
NCBI Official Synonym Full Names
phorbol-12-myristate-13-acetate-induced protein 1
NCBI Official Symbol
Pmaip1
NCBI Official Synonym Symbols
Noxa
NCBI Protein Information
phorbol-12-myristate-13-acetate-induced protein 1
UniProt Protein Name
Phorbol-12-myristate-13-acetate-induced protein 1
UniProt Gene Name
Pmaip1
UniProt Synonym Gene Names
Noxa
UniProt Entry Name
APR_MOUSE
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Product Notes
The Noxa pmaip1 (Catalog #AAA303341) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Noxa Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Noxa can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the Noxa pmaip1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Noxa, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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