IF (Immunofluorescence)
(Immunofluorescence of NPC1 in Mouse Kidney cells with NPC1 antibody at 20 μg/mL.)
Rabbit anti-Human NPC1 Polyclonal Antibody | anti-NPC1 antibody
NPC1 Antibody
Gene Names
NPC1; NPC
Reactivity
Human
Applications
Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
Purity
NPC1 Antibody is affinity chromatography purified via peptide column.
Synonyms
NPC1, Antibody; NPC1 Antibody; NPC1; NPC; Niemann-Pick C1 protein; Niemann-Pick disease, type C1; anti-NPC1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
NPC1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
1278
Applicable Applications for anti-NPC1 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
NPC1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human NPC1.
Buffer
NPC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
NPC1 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
IF (Immunofluorescence)
(Immunofluorescence of NPC1 in Mouse Kidney cells with NPC1 antibody at 20 μg/mL.)
IF (Immunofluorescence)
(Immunofluorescence of NPC1 in Mouse Kidney cells with NPC1 antibody at 20 μg/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of NPC1 in mouse kidney tissue with NPC1 antibody at 2.5 μg/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of NPC1 in mouse kidney tissue with NPC1 antibody at 2.5 μg/mL.)
WB (Western Blot)
(Western blot analysis of NPC1 in HepG2 cell lysate with NPC1 antibody at 1 μg/mL.)
WB (Western Blot)
(Western blot analysis of NPC1 in HepG2 cell lysate with NPC1 antibody at 1 μg/mL.)
Related Product Information for anti-NPC1 antibody
NPC1 Antibody: Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
107,025 Da
NCBI Official Full Name
Niemann-Pick C1 protein
NCBI Official Synonym Full Names
Niemann-Pick disease, type C1
NCBI Official Symbol
NPC1
NCBI Official Synonym Symbols
NPC
NCBI Protein Information
Niemann-Pick C1 protein
UniProt Protein Name
Niemann-Pick C1 protein
UniProt Gene Name
NPC1
UniProt Entry Name
NPC1_HUMAN
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Product Notes
The NPC1 npc1 (Catalog #AAA39335) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NPC1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NPC1 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the NPC1 npc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NPC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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