WB (Western Blot)
(Western blot analysis of Nrf2:Lane 1: MW MarkerLane 2: Rat Liver MicrosomesLane 3: Mouse Liver MicrosomesLane 4: Human Liver MicrosomesLane 5: Canine Liver MicrosomesLane 6: HeLa Cell Lysate.)
Rabbit Nrf2 Polyclonal Antibody | anti-Nrf2 antibody
Nrf2 polyclonal antibody
Gene Names
NFE2L2; NRF2; HEBP1
Reactivity
Human, Mouse, Rat, Dog, Guinea pig, Hamster
Applications
Western Blot
Purity
Protein A affinity purified.
Synonyms
Nrf2, Antibody; Nrf2 polyclonal antibody; Nuclear factor erythroid 2-related factor 2; anti-Nrf2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Guinea pig, Hamster
Clonality
Polyclonal
Purity/Purification
Protein A affinity purified.
Form/Format
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Sequence Length
605
Applicable Applications for anti-Nrf2 antibody
WB (Western Blot)
Source
Purified from rabbit serum
Immunogen
Synthetic peptide derived from the sequence of human Nrf2 (residues 40-60) with a cysteine residue added and coupled to KLH.
Preparation and Storage
Long term storage: -20 degree C
Avoid freeze/thaw cycles.
Avoid freeze/thaw cycles.
WB (Western Blot)
(Western blot analysis of Nrf2:Lane 1: MW MarkerLane 2: Rat Liver MicrosomesLane 3: Mouse Liver MicrosomesLane 4: Human Liver MicrosomesLane 5: Canine Liver MicrosomesLane 6: HeLa Cell Lysate.)
WB (Western Blot)
(Western blot analysis of Nrf2:Lane 1: MW MarkerLane 2: Rat Liver MicrosomesLane 3: Mouse Liver MicrosomesLane 4: Human Liver MicrosomesLane 5: Canine Liver MicrosomesLane 6: HeLa Cell Lysate.)
Related Product Information for anti-Nrf2 antibody
Scientific Background: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor, which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar subfamily of basic leucine zipper (CNC-bZIP) transcription factors. The NF-E2 related family comprises of Nrf1 (TCFII), Nrf2, and Nrf3 and these proteins heterodimerize with Maf proteins to bind to Maf recognition element (MARE). Under normal conditions, Nrf2 is inactive and localized in the cytoplasm through its association with Keap1. When cells are exposed to electrophiles or oxidative stress generating agents cytoplasm localization of Nrf2 is inactivated and Nrf2 translocates into the nucleus and binds to specific DNA sequence elements known as NF-E2 binding site, Maf recognition element (MARE), stress response element or anti-oxidant response element (ARE). Studies have investigated the role of Nrf2 in urinary bladder carcinogenesis, pulmonary fibrosis, and smoke-induced emphysema. A study reported Nrf2-mediated ARE transcription to be a likely target of preventative therapy in neurodegenerative disorders such as Huntington's disease.
Product Categories/Family for anti-Nrf2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
nuclear factor erythroid 2-related factor 2 isoform 1
NCBI Official Synonym Full Names
nuclear factor, erythroid 2 like 2
NCBI Official Symbol
NFE2L2
NCBI Official Synonym Symbols
NRF2; HEBP1
NCBI Protein Information
nuclear factor erythroid 2-related factor 2
UniProt Protein Name
Nuclear factor erythroid 2-related factor 2
UniProt Gene Name
NFE2L2
UniProt Synonym Gene Names
NRF2; NF-E2-related factor 2; NFE2-related factor 2
UniProt Entry Name
NF2L2_HUMAN
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Product Notes
The Nrf2 nfe2l2 (Catalog #AAA76997) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Nrf2 polyclonal antibody reacts with Human, Mouse, Rat, Dog, Guinea pig, Hamster and may cross-react with other species as described in the data sheet. AAA Biotech's Nrf2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the Nrf2 nfe2l2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nrf2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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