IHC (Immunohiostchemistry)
(NUMBL Antibody (C-term) (AAA285326)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMBL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human NUMBL Polyclonal Antibody | anti-NUMBL antibody
NUMBL Antibody (C-term)
Gene Names
NUMBL; NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
NUMBL, Antibody; NUMBL Antibody (C-term); Numb-like protein; Numb-related protein; Numb-R; NUMBL; anti-NUMBL antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This NUMBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-600 amino acids from the C-terminal region of human NUMBL.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
572-600
Sequence Length
609
Applicable Applications for anti-NUMBL antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(NUMBL Antibody (C-term) (AAA285326)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMBL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(NUMBL Antibody (C-term) (AAA285326)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMBL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(NUMBL Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the NUMBL antibody detected the NUMBL protein (arrow).)
WB (Western Blot)
(NUMBL Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the NUMBL antibody detected the NUMBL protein (arrow).)
Related Product Information for anti-NUMBL antibody
NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Product Categories/Family for anti-NUMBL antibody
References
Zhou, L., et al. Biochem. Biophys. Res. Commun. 392(3):409-414(2010)
Blom, T., et al. Cancer Genet. Cytogenet. 186(2):103-109(2008)
Ma, Q., et al. Cell. Signal. 20(6):1044-1051(2008)
Passos Gregorio, S., et al. Schizophr. Res. 88 (1-3), 275-282 (2006) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Blom, T., et al. Cancer Genet. Cytogenet. 186(2):103-109(2008)
Ma, Q., et al. Cell. Signal. 20(6):1044-1051(2008)
Passos Gregorio, S., et al. Schizophr. Res. 88 (1-3), 275-282 (2006) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
64891
NCBI Official Full Name
numb-like protein isoform a
NCBI Official Synonym Full Names
numb homolog (Drosophila)-like
NCBI Official Symbol
NUMBL
NCBI Official Synonym Symbols
NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE
NCBI Protein Information
numb-like protein
UniProt Protein Name
Numb-like protein
UniProt Gene Name
NUMBL
UniProt Synonym Gene Names
Numb-R
UniProt Entry Name
NUMBL_HUMAN
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Product Notes
The NUMBL numbl (Catalog #AAA285326) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 572-600. The NUMBL Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NUMBL can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the NUMBL numbl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NUMBL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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