Rabbit p75 NGF Receptor Polyclonal Antibody | anti-p75 NGF antibody

p75 NGF Receptor Antibody FITC-Conjugated

Cat. Num. AAA75922

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, ELISA
• Synonyms: p75 NGF Receptor, Antibody; p75 NGF Receptor Antibody FITC-Conjugated; CD271; CD271 antigen; Gp80 LNGFR; Low affinity nerve growth factor receptor; Nerve growth factor receptor; NGF receptor; NGFR; p75 ICD; p75 Neurotrophin receptor; p75 NTR; TNFR Superfamily Member 16; TNFRSF16 antibody; anti-p75 NGF antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Form/Format: FITC-Conjugated Immunoglobulins
• Sequence Length: 401

• Applicable Applications for anti-p75 NGF antibody: WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), IF (Immunofluorescence), ICC (Immunocytochemistry), ELISA, CM (Confocal Microscopy)
• Immunoglobulin & Concentration: 0.68 mg/mL IgG antibody stabilization buffer.
• Immunogen: Synthetic peptide corresponding to unique N-terminus amino acid sequence on P-75NTR protein.
• Molecular Function: Receptor
• Preparation and Storage: Store at -20°C for long term storage

Related Product Information for anti-p75 NGF antibody

The pan-neurotrophin receptor p75NTR belongs to a large family of receptors, which includes tumor necrosis factor receptors (TNF), Fas and approximately 25 other members. The p75NTR is the first receptor to be cloned and has shown significant advancement in its understanding of signaling pathways activated by p75NTR and its potential biological functions. P75NTR has surprisingly diverse effects, ranging from cell death to regulation of axon elongation. This diversity in its physiological effects can be explained by the complex formation of p75NTR with other receptor and multiple signaling molecules that interact with the intracellular domain of p75NTR (1). Neuronal survival, differentiation, and myelination also involve p75NTR signaling via Trk receptor kinases. Identification of new ligands, cytosolic interacting partners, receptor cleavage products and coreceptors for the p75NTR led to the greater understanding of p75NTR signaling (2).

Nerve growth factor (NGF) is synthesized by various structural and inflammatory cells and activates Tropomyosin-receptor kinase A (TrKA) and the p7555NTR receptor, both belong to the ‘’death receptor’’ family. One of the several diverse effects of p75NTR signaling is neuronal apoptosis that requires interaction of neurotrophin receptor interacting (NRIF) with C-Jun-N-terminal kinase (JNK) and p53 activation(3). The p75NTR has been characterized as a tumor suppressor in human prostate cancer. Administration of the p75NTR gene into subcutaneous PC-3 xenografts suppressed in a dose-dependent manner the growth of tumors (4). P75NTR has been multiple functional domains including a NTRF and a C-terminal Death domain.

The p75NTR- selective antibodies were generated using unique peptides from near N-terminal portion of the P75NTR-selective antibodies were affinity purified against immobilized antigen based affinity chromatography and are represented as pure IgG fractions stabilized in antibody stabilization buffer. Synthetic blocking peptides and western blot positive controls are available. The polyclonal antibodies strongly label as 76kDa in PC-P75NTR samples. Antibodies can be conjugated to fluorescent probes or secondary enzymes.

NCBI and Uniprot Product Information

• NCBI GI #: 5759218
• NCBI GeneID: 398129
• UniProt Accession #: Q9PRG7
• NCBI Official Full Name: p75 neurotrophin receptor a-2
• NCBI Official Symbol: p75NTRa
• NCBI Protein Information: p75 neurotrophin receptor a-1
• UniProt Protein Name: P75 neurotrophin receptor a-1
• UniProt Gene Name: p75NTRa
• UniProt Entry Name: Q9PRG7_XENLA