IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Rabbit PABPC1 Polyclonal Antibody | anti-PABPC1 antibody
PABPC1 Antibody (Center)
Gene Names
PABPC1; PAB1; PABP; PABP1; PABPC2; PABPL1
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rat, Xenopus)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
PABPC1, Antibody; PABPC1 Antibody (Center); Polyadenylate-binding protein 1; PABP-1; Poly(A)-binding protein 1; PABPC1; PAB1; PABP1; PABPC2; anti-PABPC1 antibody
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Bovine, Rat, Xenopus)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This PABPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the Central region of human PABPC1.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
250-279
Sequence Length
547
Applicable Applications for anti-PABPC1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
WB (Western Blot)
(Western blot analysis of PABPC1 Antibody (Center) in NIH-3T3 cell line lysates (35ug/lane). PABPC1 (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of PABPC1 Antibody (Center) in NIH-3T3 cell line lysates (35ug/lane). PABPC1 (arrow) was detected using the purified Pab.)
Related Product Information for anti-PABPC1 antibody
PABPC1 binds the poly(A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
References
Le Clerc,S., et.al., J. Infect. Dis. 200 (8), 1194-1201 (2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
70671
NCBI Official Full Name
polyadenylate-binding protein 1
NCBI Official Synonym Full Names
poly(A) binding protein, cytoplasmic 1
NCBI Official Symbol
PABPC1
NCBI Official Synonym Symbols
PAB1; PABP; PABP1; PABPC2; PABPL1
NCBI Protein Information
polyadenylate-binding protein 1
UniProt Protein Name
Polyadenylate-binding protein 1
UniProt Gene Name
PABPC1
UniProt Synonym Gene Names
PAB1; PABP1; PABPC2; PABP-1; Poly(A)-binding protein 1
UniProt Entry Name
PABP1_HUMAN
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Product Notes
The PABPC1 pabpc1 (Catalog #AAA285374) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 250-279. The PABPC1 Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Bovine, Rat, Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's PABPC1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the PABPC1 pabpc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PABPC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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