IHC (Immunohiostchemistry)
(PACE4/PCSK6 Antibody-Brain, Substantia Nigra)
Rabbit anti-Human PACE4/PCSK6 Polyclonal Antibody | anti-PCSK6 antibody
PACE4/PCSK6 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Gene Names
PCSK6; SPC4; PACE4
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
Immunoaffinity purified
Synonyms
PACE4/PCSK6, Antibody; PACE4/PCSK6 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody; PathPlus PACE4/PCSK6 Antibody (Cytoplasmic Domain); PCSK6; PACE4; SPC4; anti-PCSK6 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
1st cytoplasmic domain of human
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PCSK6 antibody
IHC (Immunohistochemistry), ELISA
Target
Human PACE4/PCSK6
Immunogen
Synthetic peptide-KLH conjugated
Conjugation
Unconjugated
Epitope
Cytoplasmic Domain
Family
Protease
Subfamily
Serine S8
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohiostchemistry)
(PACE4/PCSK6 Antibody-Brain, Substantia Nigra)
IHC (Immunohiostchemistry)
(PACE4/PCSK6 Antibody-Brain, Substantia Nigra)
IHC (Immunohistochemistry)
(PACE4/PCSK6 Antibody-Brain, Parkinson's neurons and Lewy Body)
IHC (Immunohistochemistry)
(PACE4/PCSK6 Antibody-Brain, Parkinson's neurons and Lewy Body)
Related Product Information for anti-PCSK6 antibody
PCSK6 antibody is an unconjugated rabbit polyclonal antibody to PCSK6 (PACE4)(Cytoplasmic Domain) from human. Validated for ELISA and IHC.
Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. PCSK6 is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine tissue, the liver, gut, and brain.
Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. PCSK6 is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine tissue, the liver, gut, and brain.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
105,375 Da
NCBI Official Full Name
proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 6
NCBI Official Symbol
PCSK6
NCBI Official Synonym Symbols
SPC4; PACE4
NCBI Protein Information
proprotein convertase subtilisin/kexin type 6; subtilisin/kexin-like protease PACE4; subtilisin-like proprotein convertase 4; paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4
UniProt Protein Name
Proprotein convertase subtilisin/kexin type 6
UniProt Gene Name
PCSK6
UniProt Synonym Gene Names
PACE4; SPC4
UniProt Entry Name
PCSK6_HUMAN
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Product Notes
The PCSK6 pcsk6 (Catalog #AAA162464) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PACE4/PCSK6 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PACE4/PCSK6 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the PCSK6 pcsk6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PACE4/PCSK6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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